3-Indoleacetic Acid-Modified Chondroitin Sulfate-Mediated Paclitaxel Nanocrystal Assembly for the Treatment of Pancreatic Cancer

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-02-04 DOI:10.1021/acsami.4c19450

Yueting Zhu, Aolei Hu, Meilin Chen, Yunting Zhang, Tao Gong, Zhirong Zhang, Ruilian Yu, Yao Fu

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Abstract

High drug-loading nanocrystals show significant advantages in delivering hydrophobic small-molecule drugs. However, these nanocrystals face challenges, including inherent instability and limited targetability. In this study, we developed a paclitaxel nanocrystal delivery platform based on chondroitin sulfate modified with 3-indoleacetic acid (CS-IAA). Paclitaxel and CS-IAA assembled into stable nanocrystals (PTX@CS-IAA, PC) with a high drug loading (up to 46.6%), facilitated by π–π stacking and hydrophobic interactions. CS-IAA targets tumors through CD44 receptors, which helps to minimize off-target effects. Additionally, CS-IAA, serving as a functional delivery vehicle, can significantly increase reactive oxygen species (ROS) levels at the tumor site. In an orthotopic pancreatic cancer mouse model, PTX@CS-IAA nanocrystals showed significantly enhanced antitumor effects. When PTX@CS-IAA was combined with the αPD-L1 antibody, the survival of mice with pancreatic tumors was further prolonged. This study provides valuable insights into alternative treatment options for pancreatic cancer, with the potential to improve patient prognosis and survival.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.