Eosinophil ETosis and Charcot-Leyden crystals in Kimura disease

The journal of allergy and clinical immunology. Global Pub Date : 2024-12-25 DOI:10.1016/j.jacig.2024.100397

Yuzaburo Inoue MD, PhD , Hitoshi Ogata MD , Yoshitake Sato MD , Daigo Kato MD, PhD , Kanako Mitsunaga MD , Mamiko Saito MD, PhD , Tatsuya Ishigaki MD, PhD , Minako Tomiita MD, PhD , Hiroshi Kuraishi MD, PhD , Keisuke Ito DDS , Shigeharu Ueki MD, PhD

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Abstract

Two cases of refractory Kimura disease that required treatment with biologic agents are reported. Their pathology suggests the involvement of eosinophil ETosis, which is active cell death producing Charcot-Leyden crystals.

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