Synergistic ameliorating effect of dithiophenolate chitosan nanoparticle and Solanum nigrum combination against lead-induced cardiotoxicity in rats

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-01-31 DOI:10.1016/j.fct.2025.115290

Bahira H. Emam , Nadia Z. Shaban , Amira Zaky , Mohammad A. AbdulKader , Shaban Y. Shaban , Nourhan M. Kolaib , Noha H. Habashy

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引用次数: 0

Abstract

Lead (Pb) toxicity is one of the most common causes of human cardiotoxicity. We evaluated the therapeutic role of Solanum nigrum extract (SNE) and dithiophenolate-chitosan nanoparticle (DTP-CSNP) on Pb-induced cardiotoxicity in rats, and the results were compared with the dimercaptosuccinic acid (DMSA, reference drug). Additionally, the combination effect of SNE and DTP-CSNP against Pb-induced cardiotoxicity was assessed. The study focused on the determination of the antioxidant, anti-inflammatory, anti-apoptotic, and cardiotherapeutic functions of SNE (375 mg/kg), DTP-CSNP (20 and 40 mg/kg), and their combination (SNE + DTP₄₀). The characterization of SNE and DTP-CSNP was studied. The results showed that SNE contains phenolics, flavonoids, ascorbic acid, and minerals, which may play an important role in its therapeutic effect. SNE, DTP₂₀, and DTP₄₀ exhibited a therapeutic impact against cardiotoxicity by reducing Pb levels, oxidative stress, inflammation, and cell death. Moreover, they regulated the abnormal levels of cardiac biomarkers induced by Pb toxicity. DTP-CSNP showed a superior therapeutic effect to DMSA, and the SNE + DTP₄₀ combination displayed a synergistic anti-cardiotoxic effect (combination index < 1). These results were in harmony with heart histopathology. Thus, the combination of both SNE and DTP-CSNP has powerful efficacy in the treatment of cardiotoxicity and can be a good alternative to DMSA.

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.