Aggregation-Mediated Photoacoustic/NIR-II and Photodynamic Properties of pH-Reversible Thiopyrylium Agents: A Computational and Experimental Approach

IF 27.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-02-03 DOI:10.1002/adma.202420006

Yishen Liu, Zhiyun Zhang, Xiaowen Hou, Qihang Ding, Silue Zeng, Hanchen Shen, Wanxia Gong, Taotao Ding, Zafar Mahmood, Xiaodong Zeng, Bingtao Ren, Wenbo Hu, Xuechuan Hong, Dan Ding, Yuling Xiao

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引用次数: 0

Abstract

Aggregation profoundly influences the photophysical properties of molecules. Here, a new series of thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, the star molecule HTPA exhibits a remarkable pH-responsive behavior and a significant increase in photoacoustic (PA) intensity when aggregated. Additionally, their behavior and pH reversibility during aggregation formation are systematically investigated, including computational optimization, femtosecond transient absorption spectroscopy, NMR analysis, and single crystal analysis. Finally, an innovative “off ” nanoparticle specifically is designed for effective tumor-targeted PA/NIR-II dual-modal imaging and photodynamic therapy by utilizing a pH-responsive polymer. The signal-to-background ratio (SBR) of PA signals significantly increased to 169 in the region of interest (ROI) in the mouse model when irradiated at 1064 nm. These findings not only provide a promising avenue for future studies of NIR-II small molecules but also pave the way for significant advances in the field of integrated cancer diagnosis and therapy.

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.