Potential benefits of ketone therapy as a novel immunometabolic treatment for schizophrenia

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research Pub Date : 2025-01-29 DOI:10.1016/j.psychres.2025.116379

Karin Huizer , Shubham Soni , Mya A. Schmidt , Nuray Çakici , Lieuwe de Haan , Jason R.B. Dyck , Nico J.M. van Beveren

引用次数: 0

Abstract

Therapeutic ketosis could target the potential bio-energetic pathophysiology of schizophrenia. Ideally, novel treatments also target the possible inflammatory aspects of schizophrenia.

Adult mice (n = 30) were treated with ketone ester (KE) or vehicle for 3 days, next LPS- or PBS-injected. Brains were collected the next day. KE significantly attenuated the increased transcription of the pro-inflammatory cytokines Tnf-a, Il-6 and Il-1b, without affecting anti-inflammatory/immunomodulatory cytokines (Il-4, Il-10, Il-11) in whole brain.

KE potently dampened neuro-inflammation in this acute inflammation mouse model. Ketone therapy could simultaneously target two possible pathophysiological pathways in schizophrenia. We encourage more research into the immunometabolic potential of therapeutic ketosis in schizophrenia.

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来源期刊

Psychiatry Research 医学-精神病学

CiteScore

17.40

自引率

1.80%

发文量

527

审稿时长

57 days

期刊介绍： Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry. The scope of the journal encompasses: Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders. Diagnostic assessments of psychiatric disorders. Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases. Evaluations of pharmacologic and non-pharmacologic psychiatric treatments. Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders. Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.