Potential for medico-biological applications of potassium sodium niobate: A review

IF 33.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Progress in Materials Science Pub Date : 2025-01-31 DOI:10.1016/j.pmatsci.2025.101448

Myint Thu , Caitlin M. Guzzo , Julia Glaum , Ashutosh Kumar Dubey , Jukka P. Matinlinna , David C. Watts , Jittima Amie Luckanagul

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引用次数: 0

Abstract

Potassium sodium niobate (KNN) is a versatile lead-free piezoelectric material with a high Curie temperature (T_c) within the range of commercial soft lead zirconate titanate (PZT). KNN-based systems can be modified to have large piezoelectric coefficients competitive with soft PZT (350–700 pC/N), albeit with lower Tc values. In recent years, utilizing its functional characteristics for a broad variety of in vivo and ex vivo medico-biological applications has been the focus of an increasing number of scientific studies. This review aimed to present state-of-the-art insights into piezoelectric KNN-based ceramics, including KNN, lithium (Li)-doped KNN, copper (Cu)-doped KNN and selenium (Se)-doped KNN, and their potential in medico-biological applications. This review described the crystallographic structure and piezoelectric properties of KNN, the manufacturing protocols and structural modification methods to improve functional properties. The sections on medico-biological applications covered topics such as tissue engineering—regeneration of bone, nerve, and cartilage—wound healing, antibacterial action, cancer therapy, drug delivery, and integrated applications with hydrogels and nanoparticles. A brief background on other piezoelectric materials and their potential for medico-biological applications was also provided. Finally, this review identified gaps in the current state-of-the-art for KNN-based ceramics pointing towards pathways for new research areas.

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来源期刊

Progress in Materials Science 工程技术-材料科学：综合

CiteScore

59.60

自引率

0.80%

发文量

101

审稿时长

11.4 months

期刊介绍： Progress in Materials Science is a journal that publishes authoritative and critical reviews of recent advances in the science of materials. The focus of the journal is on the fundamental aspects of materials science, particularly those concerning microstructure and nanostructure and their relationship to properties. Emphasis is also placed on the thermodynamics, kinetics, mechanisms, and modeling of processes within materials, as well as the understanding of material properties in engineering and other applications. The journal welcomes reviews from authors who are active leaders in the field of materials science and have a strong scientific track record. Materials of interest include metallic, ceramic, polymeric, biological, medical, and composite materials in all forms. Manuscripts submitted to Progress in Materials Science are generally longer than those found in other research journals. While the focus is on invited reviews, interested authors may submit a proposal for consideration. Non-invited manuscripts are required to be preceded by the submission of a proposal. Authors publishing in Progress in Materials Science have the option to publish their research via subscription or open access. Open access publication requires the author or research funder to meet a publication fee (APC). Abstracting and indexing services for Progress in Materials Science include Current Contents, Science Citation Index Expanded, Materials Science Citation Index, Chemical Abstracts, Engineering Index, INSPEC, and Scopus.