Trends in insecticide resistance in natural populations of Culex quinquefasciatus and its impact on mosquito fitness in Dschang, West Cameroon.

IF 1.8 3区医学 Q2 PARASITOLOGY

Parasitology Research Pub Date : 2025-01-31 DOI:10.1007/s00436-025-08457-5

Yacouba Poumachu, Michel Lontsi-Demano, Jehan Zeb, Joel Djoufounna, Borel Djiappi-Tchamen, Abeer Hashem, Reem Atalla Alajmi, Christelle Layelle Mochie, Herman Parfait Awono-Ambene, Christophe Antonio-Nkondjio, Timoléon Tchuinkam, Elsayed Fathi Abd-Allah

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Abstract

Specific information about the dispersion of Culex quinquefasciatus from Dschang in western Cameroon is scarce, and evidence-based interventions are needed. Common use of larvicides and adulticides conduct to the development of vectors resistance which can lead to deep biological changes, including fitness costs. We assessed the profile of insecticide resistance in field populations of Cx. quiquefasciatus and its potential fitness cost in a lineage selected for deltamethrin and permethrin resistance in the laboratory for two generations. The resistance intensity of the Cx. quinquefasciatus population was moderated when the population was exposed to deltamethrin at 10 × . Preexposure to PBO led to the restoration of full susceptibility to both deltamethrin and permethrin. Compared with that of the control group, female fecundity rates, egg hatchability, and pupation rates were significantly lower in the insecticide exposed groups. Larval development time and adults emergence rates were comparable between insecticide-exposed groups and the control. Insecticide-exposed adults lived longer than control adults did. Our findings suggest that the mechanisms selected for pyrethroid resistance are associated with negative impacts on different life-trait parameters and support the hypothesis that insecticide resistance is related to a high fitness cost.

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喀麦隆西部Dschang地区致倦库蚊自然种群杀虫剂抗性趋势及其对蚊虫适合度的影响

关于喀麦隆西部Dschang地区致倦库蚊分布的具体信息很少，需要采取循证干预措施。普遍使用杀幼虫剂和杀成虫剂会导致病媒产生抗药性，从而导致深刻的生物学变化，包括适应成本。本研究评估了小棉铃虫田间种群对杀虫剂的抗性。对溴氰菊酯和氯菊酯抗性进行实验室两代筛选的库蚊及其潜在适应度成本。Cx的电阻强度。溴氰菊酯浓度为10倍时，致倦库蚊种群数量有所减少。预暴露于PBO导致对溴氰菊酯和氯菊酯的完全敏感性恢复。与对照组相比，杀虫剂暴露组雌蜂产卵率、卵孵化率和化蛹率均显著降低。杀虫剂暴露组和对照组的幼虫发育时间和成虫羽化率具有可比性。接触杀虫剂的成年人比对照组的成年人寿命更长。我们的研究结果表明，拟除虫菊酯抗性机制的选择与不同生命特征参数的负面影响有关，并支持了杀虫剂抗性与高适应成本相关的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parasitology Research 医学-寄生虫学

CiteScore

4.10

自引率

5.00%

发文量

346

审稿时长

6 months

期刊介绍： The journal Parasitology Research covers the latest developments in parasitology across a variety of disciplines, including biology, medicine and veterinary medicine. Among many topics discussed are chemotherapy and control of parasitic disease, and the relationship of host and parasite. Other coverage includes: Protozoology, Helminthology, Entomology; Morphology (incl. Pathomorphology, Ultrastructure); Biochemistry, Physiology including Pathophysiology; Parasite-Host-Relationships including Immunology and Host Specificity; life history, ecology and epidemiology; and Diagnosis, Chemotherapy and Control of Parasitic Diseases.