A comprehensive outline of the role of non-coding RNAs in vitiligo

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-01-09 DOI:10.1016/j.bbrep.2025.101916

Fateme Sadat Feghahati, Soudeh Ghafouri-Fard

引用次数: 0

Abstract

Vitiligo is a common skin depigmentation condition caused by selective destruction of melanocytes. It is regarded as a polygenic disorder. In addition to protein-coding loci, non-coding regions of the genome contribute to the pathogenesis of vitiligo. A bulk of evidence highlights contribution of different classes of non-coding RNAs in this condition. Expression profile of different non-coding RNAs has been evaluated in the plasma, serum, blood cells and skin samples of patients with vitiligo. Notably, these transcripts not only partake the pathogenesis of vitiligo, but also are regarded as putative targets for prospective treatment strategies for this disorder. The current review focuses on depicting the role of miRNAs, long non-coding RNAs and circular RNAs in the etiology of vitiligo. Moreover, we discuss the shared functions of these transcripts in the pathogenesis of vitiligo and melanoma.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.