Aesthetic Efficacy and Safety of Combined Microfocused Ultrasound With Visualization and Calcium Hydroxylapatite Treatment: A Systematic Review of Human Evidence.
Mojgan Amiri, Renald Meçani, Christa D Niehot, Guido Muharremi, Julieta Spada, Rossana Vasconcelos, Tatjana Pavicic, Sonja Sattler, Melissa K Levin, Siew Tuck Wah, Julia Carroll, Sonya Cook, Taulant Muka
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引用次数: 0
Abstract
Although microfocused ultrasound with visualization (MFU-V) and calcium hydroxylapatite- carboxymethylcellulose (CaHA-CMC) have their individual strengths and have demonstrated effectiveness in aesthetic improvement and improving skin laxity, a combined treatment may sometimes be required to achieve comprehensive aesthetic enhancements that meet patients' needs and preferences. This review systematically summarizes the available evidence on combined MFU-V and CaHA-CMC treatment. A comprehensive search was conducted in Embase, MEDLINE ALL (Ovid), Web of Science Core Collection, and Cochrane Central. We included studies conducted in adults that examined the effectiveness, safety, and/or mechanism of action of combined MFU-V and CaHA-CMC treatment. Out of 4019 references, 11 studies, mainly pre-post studies, were included in this analysis. Overall, regardless of the area treated, improvements in global aesthetic scales, skin quality parameters, and patients' satisfaction following combined treatment, accompanied by mild to moderate adverse effects, were found. In addition, histological studies indicated increased neocollagenesis and elastin synthesis posttreatment. Our review highlights promising outcomes from combined MFU-V and CaHA-CMC treatment. Nevertheless, due to the limited number of studies, further research is essential to gain a deeper understanding of this combined treatment's efficacy, safety, and applicability.
尽管可视化微聚焦超声（MFU-V）和羟基磷灰石钙-羧甲基纤维素（CaHA-CMC）具有各自的优势，并且在改善美观和改善皮肤松弛方面已被证明有效，但有时可能需要联合治疗来实现全面的美观增强，以满足患者的需求和偏好。本文系统总结了MFU-V和CaHA-CMC联合治疗的现有证据。在Embase、MEDLINE ALL （Ovid）、Web of Science Core Collection和Cochrane Central中进行了全面的检索。我们纳入了在成人中进行的研究，这些研究检查了MFU-V和CaHA-CMC联合治疗的有效性、安全性和/或作用机制。在4019篇文献中，有11篇研究被纳入本分析，主要是前后研究。总体而言，无论治疗的区域如何，综合治疗后的整体美学尺度、皮肤质量参数和患者满意度均有所改善，并伴有轻度至中度的不良反应。此外，组织学研究表明，治疗后新胶原生成和弹性蛋白合成增加。我们的综述强调了MFU-V和CaHA-CMC联合治疗的良好结果。然而，由于研究数量有限，需要进一步的研究来更深入地了解这种联合治疗的有效性、安全性和适用性。证据等级：3（治疗性）：
期刊介绍：
Aesthetic Surgery Journal is a peer-reviewed international journal focusing on scientific developments and clinical techniques in aesthetic surgery. The official publication of The Aesthetic Society, ASJ is also the official English-language journal of many major international societies of plastic, aesthetic and reconstructive surgery representing South America, Central America, Europe, Asia, and the Middle East. It is also the official journal of the British Association of Aesthetic Plastic Surgeons, the Canadian Society for Aesthetic Plastic Surgery and The Rhinoplasty Society.
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