Cobalt polygalacturonates and the pharmacological composition based on them: Preparation, properties and cytotoxicity.

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI:10.1016/j.ijbiomac.2025.140377

Salima T Minzanova, Evgenii V Chekunkov, Anna V Khabibullina, Lubov G Mironova, Alexandra D Voloshina, Anna P Lyubina, Kirill V Kholin, Guliya R Nizameeva, Airat R Khamatgalimov, Vasili A Milyukov

{"title":"Cobalt polygalacturonates and the pharmacological composition based on them: Preparation, properties and cytotoxicity.","authors":"Salima T Minzanova, Evgenii V Chekunkov, Anna V Khabibullina, Lubov G Mironova, Alexandra D Voloshina, Anna P Lyubina, Kirill V Kholin, Guliya R Nizameeva, Airat R Khamatgalimov, Vasili A Milyukov","doi":"10.1016/j.ijbiomac.2025.140377","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of the present study was to obtain new metal complexes of citrus pectin with cobalt ions based on potassium polygalacturonate and to prepare a new pharmacological composition (PC) PGKCo: PGNaCo (1:1) with antitumor activity based on potassium cobalt polygalacturonate (PGKCo) and sodium cobalt polygalacturonate (PGNaCo). The study of the effect of PGKCo, PGNaCo and PC on the cell viability of tumor cell lines of different genesis in vitro showed that the obtained compounds are soluble in water and exhibit selective cytotoxic activity against the tumor cell lines of human lung carcinoma A549, breast adenocarcinoma MCF-7 and cervical carcinoma M-HeLa, with no significant toxic effect on normal human cells. The possible mechanism of action of the investigated PC on M-HeLa cancer cells was investigated. The mechanism of action of PC was found to be associated with cell cycle arrest in the G0/G1 phase and the induction of apoptosis through the mitochondrial pathway. The results obtained indicate the potential for the non-toxic compounds (PGKCo, PGNaCo and PC) to be developed as drugs for the complex treatment of oncologic diseases.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140377"},"PeriodicalIF":7.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biological Macromolecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.ijbiomac.2025.140377","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The aim of the present study was to obtain new metal complexes of citrus pectin with cobalt ions based on potassium polygalacturonate and to prepare a new pharmacological composition (PC) PGKCo: PGNaCo (1:1) with antitumor activity based on potassium cobalt polygalacturonate (PGKCo) and sodium cobalt polygalacturonate (PGNaCo). The study of the effect of PGKCo, PGNaCo and PC on the cell viability of tumor cell lines of different genesis in vitro showed that the obtained compounds are soluble in water and exhibit selective cytotoxic activity against the tumor cell lines of human lung carcinoma A549, breast adenocarcinoma MCF-7 and cervical carcinoma M-HeLa, with no significant toxic effect on normal human cells. The possible mechanism of action of the investigated PC on M-HeLa cancer cells was investigated. The mechanism of action of PC was found to be associated with cell cycle arrest in the G0/G1 phase and the induction of apoptosis through the mitochondrial pathway. The results obtained indicate the potential for the non-toxic compounds (PGKCo, PGNaCo and PC) to be developed as drugs for the complex treatment of oncologic diseases.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.