Fingolimod-associated cryptococcal meningitis in a patient with Multiple Sclerosis: A case report and literature review

Abstract

A 65-year-old woman with Multiple Sclerosis treated with fingolimod developed headaches and convulsions. Cerebrospinal fluid (CSF) culture indicated Cryptococcus neoformans. A literature review of 20 cases of cryptococcal meningitis indicated that headache was the most common initial symptom, and all cases were positive for serum and/or CSF cryptococcal antigens.