Application of Contrast-Enhanced Ultrasound Parameters of Metastatic Axillary Lymph Nodes in Breast Cancer Patients in Predicting the Efficacy of Neoadjuvant Chemotherapy in Early Stage.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-01-29 DOI:10.1002/jcu.23922

Jiawei Sun, Qingzhuo Zhao, Yan He, Xianli Zhou

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引用次数: 0

Abstract

Background: To investigate the performance of contrast-enhanced ultrasound(CEUS) parameters of metastatic axillary lymph nodes (ALNs) before and after two courses of neoadjuvant chemotherapy (NAC) in breast cancer patients in predicting the efficacy of NAC.

Methods: A total of 41 postoperative breast cancer patients were selected. All patients underwent NAC, and ALN biopsy was positive before chemotherapy. Metastatic ALN was examined by CEUS before and after two courses of NAC. The CEUS parameters of metastatic ALNs before and after two courses of NAC were analyzed to determine the performance of CEUS parameters in predicting the efficacy of NAC in early stage.

Results: The NAC was effective for 28 cases and ineffective for 13 cases. There were no statistically significant differences in the CEUS parameters between effective NAC and ineffective NAC individuals before and after two courses of NAC. But, there were statistically significant differences in long diameter (LD), short diameter (SD), Peak intensity (Peak%) and area under the curve (AUC) between the effective and ineffective NAC patients after two courses of NAC. Receiver operating characteristic curve (ROC) analysis suggested the drop-out value of LD, SD, Peak% and AUC after two courses of NAC can be used as important indicators to evaluate the efficacy of NAC (p < 0.05).

Conclusions: CEUS parameters of metastatic axillary lymph nodes (ALNs) before and after two courses of neoadjuvant chemotherapy (NAC) in breast cancer patients can predict the efficacy of NAC in early stage.

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.