Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-01-30 DOI:10.1002/alz.14518

Xuan Lu, Shanshan Bai, Lu Feng, Xu Yan, Yuejun Lin, Junzhe Huang, Xulin Liao, Haixing Wang, Linlong Li, Zhengmeng Yang, Leo Yik Chun Yan, Boguang Yang, Ming Wang, Jiakang Jin, Zhixian Zong, Zhaowei Jiang, Chuiguo Huang, Chaoran Liu, Xiaoting Zhang, Han Su, Yaofeng Wang, Wayne Yuk-Wai Lee, Xiaohua Jiang, Micky D. Tortorella, Sien Lin, Ho Ko, Gang Li

引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be a potential therapeutic strategy for AD. Our proof-of-concept study demonstrated that cranial bone transport can improve meningeal lymphatic drainage function and promote ischemic stroke recovery.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.