Lewis Acid Catalyzed Divergent Synthesis of Polysubstituted Furans and Pyrroles

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-01-29 DOI:10.1039/d4qo02216e

Chenguang Li, Tongxiang Cao, Shifa Zhu

引用次数: 0

Abstract

The development of an advisable strategy to obtain the biologically relevant polysubstituted furans and pyrroles is a highly anticipated yet challenging task. Here we report an efficient synthetic strategy for the rapid construction of multisubstituted C2-furan or pyrrole carboxylic acid derivatives via a cascade reaction from simple and readily available starting materials. This catalytic protocol characterized by inexpensive Lewis catalysts as well as high atom economy, provides access to a wide variety of tri-, and tetrasubstituted furan/pyrrole derivatives in excellent yields. Gram-scale synthesis and synthetic applications are demonstrated.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.