Cardiovascular Implications of Non-steroidal Anti-inflammatory Drugs: A Comprehensive Review, with Emphasis on Patients with Rheumatoid Arthritis.

European cardiology Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI:10.15420/ecr.2024.24
Eirik Ikdahl, Anne Kerola, Eli Sollerud, Anne Grete Semb
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Abstract

This review examines the cardiovascular risks associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), both traditional NSAIDs and cyclooxygenase-2 selective inhibitors (COXIBs). It describes the history of traditional NSAIDs and the development of COXIBs to explain why their cardiovascular side effects were unnoticed for many decades. Further, the review presents the mechanism of action of NSAIDs, to elucidate the possible underlying basis for why they are associated with an increased risk of cardiovascular disease. Finally, data on the cardiovascular risk with NSAID use in patients with rheumatoid arthritis are presented, and we propose possible explanations for why the risk of cardiovascular side effects in these patients seems to be less pronounced than in the general population.

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非甾体抗炎药对心血管的影响:非类固醇抗炎药物对心血管的影响:以类风湿性关节炎患者为重点的全面综述》。
本综述探讨了使用非甾体抗炎药(NSAIDs)的心血管风险,包括传统的非甾体抗炎药和环氧化酶-2选择性抑制剂(coxib)。它描述了传统非甾体抗炎药的历史和coxib的发展,以解释为什么几十年来它们的心血管副作用被忽视。此外,本综述提出了非甾体抗炎药的作用机制,以阐明它们与心血管疾病风险增加相关的可能基础。最后,介绍了类风湿性关节炎患者使用非甾体抗炎药的心血管风险的数据,并提出了这些患者心血管副作用风险似乎比一般人群不那么明显的可能解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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