mSphere of Influence: The challenge of screening for essential protein kinases in Trypanosoma cruzi.

IF 3.7 2区生物学 Q2 MICROBIOLOGY

mSphere Pub Date : 2025-02-25 Epub Date: 2025-01-28 DOI:10.1128/msphere.00598-24

Miguel A Chiurillo

引用次数: 0

Abstract

Miguel Chiurillo works in the field of protein kinases, studying their role in cell signaling and cell cycle progression in Trypanosoma cruzi. In this mSphere of Influence article, he reflects on how the research articles "Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival" by Baker et al. and "Screening the Toxoplasma kinome with high throughput tagging identifies a regulator of invasion and egress" by Smith et al. made an impact on his understanding of the complexity of the Trypanosoma cruzi kinome and the challenges to unravel it.

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影响范围：克氏锥虫必需蛋白激酶筛选的挑战。

Miguel Chiurillo在蛋白激酶领域工作，研究它们在克氏锥虫细胞信号传导和细胞周期进程中的作用。在这篇影响范围的文章中，他反思了Baker等人的研究文章“利什曼原虫蛋白激酶的系统功能分析识别分化或生存的调节因子”和Smith等人的“用高通量标记筛选弓形虫kinome识别入侵和退出的调节因子”如何影响他对克氏锥虫kinome复杂性的理解以及揭示它的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

mSphere Immunology and Microbiology-Microbiology

CiteScore

8.50

自引率

2.10%

发文量

192

审稿时长

11 weeks

期刊介绍： mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.