Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 588 patients with oral lichen planus

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-01-01 DOI:10.1016/j.jds.2024.11.014

Yu-Hsueh Wu , Julia Yu-Fong Chang , Yi-Pang Lee , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang

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引用次数: 0

Abstract

Background/purpose

Our previous study found that 21.9 %, 13.6 %, 7.1 %, 0.3 %, and 14.8 % of 352 oral lichen planus (OLP) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. This study mainly evaluated the anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in a large group of 588 OLP patients.

Materials and methods

The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 588 OLP patients were measured and compared with the corresponding levels in 588 age- and sex-matched healthy control subjects.

Results

We found that 148 (25.2 %), 99 (16.8 %), 60 (10.2 %), 7 (1.2 %), 124 (21.1 %), and 139 (23.6 %) OLP patients had blood Hb, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 588 OLP patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.001 except P = 0.023 for folic acid deficiency). Of 148 anemic OLP patients, 68 had normocytic anemia, 32 had iron deficiency anemia, 19 had thalassemia trait-induced anemia, 17 had pernicious anemia, 7 had macrocytic anemia other than pernicious anemia, and 5 had microcytic anemia other than iron deficiency anemia and thalassemia trait-induced anemia.

Conclusion

OLP patients have significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects.

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588例口腔扁平苔藓患者的贫血、血凝素缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体阳性

背景/目的：我们之前的研究发现352例口腔扁平苔藓（OLP）患者中分别有21.9%、13.6%、7.1%、0.3%和14.8%存在贫血、血清铁、维生素B12和叶酸缺乏以及高同型半胱氨酸血症。本研究主要评估588例OLP患者的贫血、血凝素缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体（GPCA）阳性。材料与方法：测定588例OLP患者的血红蛋白（Hb）、血清铁、维生素B12、叶酸、同型半胱氨酸和GPCA水平，并与588例年龄和性别匹配的健康对照进行比较。结果：我们发现OLP患者分别有148例（25.2%）、99例（16.8%）、60例（10.2%）、7例（1.2%）、124例（21.1%）和139例（23.6%）存在血Hb、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性。此外，588例OLP患者血Hb和血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性的频率显著高于588例健康对照（叶酸缺乏的P值均为P = 0.023）。148例贫血性OLP患者中，正常细胞性贫血68例，缺铁性贫血32例，地中海贫血特发性贫血19例，恶性贫血17例，大细胞性贫血非恶性贫血7例，小细胞性贫血非缺铁性贫血和地中海贫血特发性贫血5例。结论：OLP患者血Hb、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性的频率明显高于健康对照组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.