T-2 Toxin Nephrotoxicity: Toxic Effects, Mechanisms, Mitigations, and Future Perspectives

Abstract

T-2 toxin is a highly toxic fungal toxin that threatens humans and animals’ health. As a major detoxifying and metabolic organ, the kidney is also a target of T-2 toxin. This article reviews T-2 toxin nephrotoxicity research progress, covering renal structure and function damage, nephrotoxicity mechanisms, and detoxification methods to future research directions. T-2 toxin damages kidney structure, causing renal dysfunction. The nephrotoxicity mechanism of T-2 toxin involves multiple factors including oxidative stress, endoplasmic reticulum stress, mitophagy, inflammatory responses, and apoptosis, which are intertwined and interdependent. Current detoxification strategies mainly involve reducing T-2 toxin in feedstuff and using antioxidant substances, but both have limits. Future research should focus on renal cells sensitivity to T-2 toxin, exploring key molecules in T-2 toxin’s nephrotoxicity, renal injury’s impact on other organs, and better detoxification methods. This review aims to guide future research and underpin T-2 toxin-induced nephrotoxicity prevention and treatment.