Intoxication of sheep by Astragalus arequipensis in northwestern Argentina.

IF 1.2 3区农林科学 Q3 VETERINARY SCIENCES

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI:10.1177/10406387241311815

Raul E Marin, Dale Gardner, Daniel Cook, Anibal G Armien, Renée H Fortunato, Franklin Riet-Correa, Francisco A Uzal

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Abstract

Spontaneous intoxication by Astragalus arequipensis was diagnosed in a flock of 300 sheep in Jujuy province, northwestern Argentina, that grazed an area heavily invaded by this plant. The main clinical signs were intention tremors, ataxia, and progressive loss of condition. Autopsy of 2 affected animals revealed loss of body condition. The main microscopic changes were fine cytoplasmic vacuolation of cells in the cerebrum, cerebellum, thyroid and adrenal glands, kidney, liver, pancreas, urinary bladder, and lymph nodes, and swollen axons in the cerebellum. Ultrastructurally, the cytoplasmic vacuoles consisted of dilated secondary lysosomes. Composite leaf and stem samples of A. arequipensis analyzed by high-performance liquid chromatography contained 0.05% swainsonine. The diagnosis of intoxication by A. arequipensis was made based on the clinical history and signs; gross, microscopic, and ultrastructural changes; and detection of swainsonine in the plant.

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阿根廷西北部羊被黄芪中毒。

阿根廷西北部胡胡伊省的300只羊被黄芪自发中毒，这些羊在该植物严重入侵的地区吃草。主要临床症状为心性震颤、共济失调和病情进行性丧失。2只受感染动物的尸检显示身体状况丧失。显微镜下主要表现为大脑、小脑、甲状腺、肾上腺、肾脏、肝脏、胰腺、膀胱、淋巴结细胞的细胞质空泡化，小脑轴突肿胀。超微结构上，细胞质空泡由扩张的次级溶酶体组成。高效液相色谱法分析了马马辛素含量为0.05%的马马辛素复合样品。根据临床病史和体征对毒弓形虫中毒进行诊断；肉眼、显微镜和超微结构的变化；以及植物中苦马豆素的检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Diagnostic Investigation 农林科学-兽医学

CiteScore

3.00

自引率

6.70%

发文量

127

审稿时长

6-16 weeks

期刊介绍： The Journal of Veterinary Diagnostic Investigation (J Vet Diagn Invest) is an international peer-reviewed journal published bimonthly in English by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). JVDI is devoted to all aspects of veterinary laboratory diagnostic science including the major disciplines of anatomic pathology, bacteriology/mycology, clinical pathology, epidemiology, immunology, laboratory information management, molecular biology, parasitology, public health, toxicology, and virology.