New approaches in childhood IgE-mediated food allergy treatment.

IF 3 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI:10.1097/ACI.0000000000001058

Deniz Ilgun Gurel, Aikaterini Anagnostou, Alessandro Fiocchi, Chinthrajah Sharon, Umit Sahiner, Sayantani Sindher, Stefania Arasi

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Abstract

Purpose of review: This review aims to provide an overview of the current and future treatment options for children with food allergies (FAs), highlighting the latest research findings and the potential impact of these new approaches on improving patients' and caregivers' quality of life.

Recent findings: In the last decade, many promising approaches have emerged as an alternative to the standard avoidance of the culprit food with the risk of severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings as a therapeutic approach, and more recently also omalizumab. In addition, alternative routes of administration for immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, and PVX108 are being investigated.

Summary: The portfolio of available treatment options for food allergies is increasing but several relevant unmet needs remain. This review aims to provide a brief overview of the existing and future treatment options for IgE-mediated food allergies.

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儿童ige介导的食物过敏治疗新途径

综述目的：本综述旨在概述目前和未来食物过敏（FAs）儿童的治疗方案，重点介绍最新研究结果以及这些新方法对改善患者和护理人员生活质量的潜在影响。最近的发现：在过去的十年里，许多有希望的方法已经出现，作为标准的避免有严重意外反应风险的罪魁祸首食物的替代方案。通过口服免疫疗法脱敏已被引入临床环境作为一种治疗方法，最近也引入了奥玛珠单抗。此外，免疫治疗、其他生物制剂、小分子、益生菌或益生元、微生物群移植治疗、IGNX001和PVX108的替代给药途径正在研究中。摘要：食物过敏的可用治疗方案正在增加，但仍有一些相关的需求未得到满足。本文综述了ige介导的食物过敏的现有和未来治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.