Lanostane Triterpenes, Flavanones and Acetogenins from the Roots of Uvaria siamensis and Their Cytotoxic Activity.

IF 3.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-01-07 eCollection Date: 2025-01-21 DOI:10.1021/acsomega.4c09267

Lueacha Tabtimmai, Kiattawee Choowongkomon, Prasat Kittakoop, Ratsami Lekphrom, Florian Thierry Schevenels, Supachai Jadsadajerm, Awat Wisetsai

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Abstract

Our phytochemical investigation of the roots of Uvaria siamensis led to the isolation of two new lanostane triterpenes, 3-acetylpolycarpol (1) and 15-acetylpolycarpol (2), as well as 15 known compounds (3-17). The structures of the isolated compounds were elucidated by an analysis of spectroscopic data. Compounds 1-9 were tested against nonsmall cell lung cancer cells (A549) and human cervical carcinoma cells (HeLa) using an MTT assay. Polycarpol (3) and uvariamicin-II (9) exhibited potent cytotoxicity against A549 cancer cells, while 15-acetylpolycarpol (2) and pinocembrin (4) displayed potent cytotoxicity against HeLa cancer cells. Further analysis of the apoptosis-inducing properties revealed that uvariamicin-II (9) and pinocembrin (4) induced apoptosis in a dose-dependent manner in A549 and HeLa cells, respectively. These two compounds also showed weak cytotoxicity toward Vero cells.

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通过对暹罗乌蔹莓根部的植物化学研究，我们分离出了两种新的羊角甾三萜类化合物：3-乙酰基聚carpol（1）和 15-乙酰基聚carpol（2），以及 15 种已知化合物（3-17）。通过分析光谱数据，阐明了分离出的化合物的结构。利用 MTT 法测试了 1-9 化合物对非小细胞肺癌细胞（A549）和人类宫颈癌细胞（HeLa）的作用。Polycarpol (3) 和 uvariamicin-II (9) 对 A549 癌细胞显示出了强大的细胞毒性，而 15-acetylpolycarpol (2) 和 pinocembrin (4) 则对 HeLa 癌细胞显示出了强大的细胞毒性。对凋亡诱导特性的进一步分析表明，乌伐霉素-II（9）和松果菊素（4）分别以剂量依赖的方式诱导 A549 和 HeLa 细胞凋亡。这两种化合物对 Vero 细胞也有微弱的细胞毒性。

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.