Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-01-27 DOI:10.1002/alz.14548

Wassim Elyaman, Lawrence J. Stern, Ning Jiang, Dallin Dressman, Philip Bradley, David Klatzmann, Elizabeth M. Bradshaw, Donna L. Farber, Sally C. Kent, Shahab Chizari, Kristen Funk, Davangere Devanand, Kiran T. Thakur, Towfique Raj, Osama Al Dalahmah, Rani A. Sarkis, Howard L. Weiner, Neil A. Shneider, Serge Przedborski

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引用次数: 0

Abstract

This proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia–T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau. The symposium also examined immunotherapies for AD, including the Valacyclovir Treatment of Alzheimer's Disease (VALAD) trial, and two clinical trials leveraging regulatory T cell approaches for multiple sclerosis and amyotrophic lateral sclerosis therapy. Additionally, single-cell RNA/TCR sequencing of T cells and other immune cells provided insights into immune dynamics in neurodegenerative diseases. This article highlights key findings from the symposium and outlines future research directions to further understand the role of T cells in neurodegeneration, offering innovative therapeutic approaches for AD and other neurodegenerative diseases.

Highlights

Researchers gathered to discuss approaches to study T cells in brain disorders.
New technologies allow high-throughput screening of antigen-specific T cells.
Microbial infections can precede several serious and chronic neurological diseases.
Central and peripheral T cell responses shape neurological disease pathology.
Immunotherapy can induce regulatory T cell responses in neuroinflammatory disorders.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.