Alternative biological models for evaluation of the toxic, genotoxic and mutagenic potential of Ectatomma brunneum Smith venom

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2025-02-01 DOI:10.1016/j.toxicon.2025.108256

Bruno do Amaral Crispim , Rafaella Caroline Bernardi , Sabrina Rodrigues da Luz , Hélina dos Santos Nascimento , Fabiana Gomes da Silva Dantas , Kelly Mari Pires de Oliveira , Marina Stefanes Schibichewski , Cláudia Andrea Lima Cardoso , Alexeia Barufatti

引用次数: 0

Abstract

The venom of Ectatomma brunneum is considered promising for drugs development. Therefore, it is important to evaluate its toxic potential and genetic instability using biological assays. To this end, toxicity assays were performed with Artemia salina, cytotoxicity and genotoxicity with Allium cepa and mutagenicity with Ames. The results indicated toxicity to A. salina, and no cytotoxic, genotoxic or mutagenic potential at concentrations equal to or lower than 500 μg/mL for the other tests.

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评价褐褐褐眼肿毒毒性、遗传毒性和致突变潜能的替代生物学模型。

brunneum异位瘤的毒液被认为有希望用于药物开发。因此，用生物学方法评估其毒性和遗传不稳定性是很重要的。为此，对盐蒿进行了毒性试验，对葱进行了细胞毒性和遗传毒性试验，对艾姆斯进行了诱变性试验。结果表明，在浓度等于或低于500 μg/mL时，对盐芽孢杆菌具有毒性，其他试验无细胞毒性、基因毒性或诱变潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

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