Nateglinide: A comprehensive profile.

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI:10.1016/bs.podrm.2024.10.002

Manal M Alanazi

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Abstract

Nateglinide belongs to the meglitinide class of insulin secretagogues. It is used as an oral hypoglycemic agent for the treatment of type 2 diabetes mellitus. Nateglinide is an amino acid derivative of D-phenylalanine that binds to the ATP-sensitive potassium channels in pancreatic beta cells and stimulates the secretion of insulin. In this chapter, various aspects of Nateglinide are discussed. This includes methods used for its synthesis, physicochemical properties, and different techniques employed to determine its structure, such as elemental analysis, IR, UV, (¹H and ¹³C) NMR, MS, and XRD. Additionally, the chapter covers a literature review of various methods of analysis of Nateglinide, such as X-ray powder diffraction pattern analysis, differential scanning calorimetry, spectrophotometric, chromatographic, capillary electrophoresis and immunoassay methods. Moreover, the pharmacology of the title drug including pharmacokinetics, pharmacodynamics, mechanism of action, drug-drug and drug-food interactions are also reviewed.

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那格列奈：一个全面的概况。

那格列奈属于美格列奈类胰岛素促分泌剂。它被用作治疗2型糖尿病的口服降糖药。那格列奈是d -苯丙氨酸的一种氨基酸衍生物，与胰腺β细胞中atp敏感的钾通道结合，刺激胰岛素的分泌。在本章中，讨论了那格列奈的各个方面。这包括用于其合成的方法，物理化学性质，以及用于确定其结构的不同技术，如元素分析，IR， UV, (1H和13C) NMR， MS和XRD。此外，本章还涵盖了对那格列奈各种分析方法的文献综述，如x射线粉末衍射分析、差示扫描量热法、分光光度法、色谱法、毛细管电泳法和免疫分析法。此外，还综述了标题药物的药理学，包括药代动力学、药效学、作用机制、药物-药物和药物-食品相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

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