THE RATIO OF EXCITATORY AND INHIBITORY SYNAPTIC PROCESSES IN NEURONS OF THE ЕNTORHINAL CORTEX OF THE BRAIN, ACTIVATED BY BASOLATERAL AMYGDALA ON THE MODEL OF PARKINSON'S DISEASE, UNDER CONDITIONS OF PROTECTION BY HYDROCORTISONE.

Q4 Medicine
Georgian medical news Pub Date : 2024-11-01
V Hovsepyan, G Arajyan, A Al-Chachani, G Musheghyan, J Sarkissian, I Gabrielyan
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引用次数: 0

Abstract

Parkinson disease (PD) is a common neurodegenerative condition. It affects the central nervous system, and it impairs cognitive processes, motor skills and other functions. The aim of this study was to determine the synaptic processes in medial Entorhinal cortex (mENT) under High frequency stimulation of Basolateral Amygdala on the model of Parkinson's disease under the influence of Hydrocortisone. Rotenone is involved in the degeneration of dopaminergic neurons. We investigated whether hydrocortison protects against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from medial Entorhinal cortex. Hydrocortison significantly improved electrical activity of neurons in the mENT of rotenone-induced PD model rats.

在氢化可的松保护条件下,基底外侧杏仁核在帕金森病模型上激活的大脑Еntorhinal皮层神经元兴奋性和抑制性突触过程的比例。
帕金森病(PD)是一种常见的神经退行性疾病。它会影响中枢神经系统,损害认知过程、运动技能和其他功能。本研究旨在探讨氢化可的松作用下帕金森病模型基底外侧杏仁核高频刺激下内侧内嗅皮质(mENT)的突触过程。鱼藤酮参与多巴胺能神经元的退化。我们在大鼠模型中通过内嗅皮层的体内电记录研究了氢化可的松是否对鱼藤酮诱导的多巴胺能神经毒性有保护作用。氢化可的松显著改善鱼藤酮诱导的PD模型大鼠mENT神经元电活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Georgian medical news
Georgian medical news Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
207
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