{"title":"Evaluation of the effects of obesity on orthodontic tooth movement.","authors":"Mustafa Uzun, Mine Geçgelen Cesur, Ömer Erdoğan","doi":"10.4041/kjod24.001","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate bone remodeling in gingival crevicular fluid (GCF) during canine distalization in obese individuals and compare it to that in normal-weight individuals. Additionally, the orthodontic tooth movement rates of obese individuals were measured and compared with those of normal-weight individuals.</p><p><strong>Methods: </strong>Thirty-six patients (18 obese and 18 normal-weight) aged 12-18 years who were candidates for maxillary first premolar extraction for Angle Class II malocclusion were included in the study. The two groups were formed according to World Health Organization guidelines. A normal-weight group (body mass index [BMI] 16-85%) and an obese group (BMI ≥ 95%). Gingival crevicular fluid samples were collected before, 24 hours after, and on the 7th, 14th, and 21st days after the application of the distalization force. Enzyme-linked immunosorbent assay was used to measure leptin, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and interleukin-6 (IL-6) levels in GCF samples. In addition to the recorded GCF sampling times, the amount of canine tooth movement was calculated using digital models obtained on the 28th day and 3rd month.</p><p><strong>Results: </strong>Leptin, RANKL, OPG, and IL-6 levels were significantly higher in the obese group (<i>P</i> < 0.05). The digital model measurements displayed high rates of repeatability (ICC 0.990). The difference in the amount of tooth movement between groups was not statistically significant (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>Although obese and normal-weight individuals showed different biomarker levels during tooth movement, there were no significant differences in the amount of movement.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 1","pages":"3-14"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788180/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Orthodontics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4041/kjod24.001","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/29 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aimed to evaluate bone remodeling in gingival crevicular fluid (GCF) during canine distalization in obese individuals and compare it to that in normal-weight individuals. Additionally, the orthodontic tooth movement rates of obese individuals were measured and compared with those of normal-weight individuals.
Methods: Thirty-six patients (18 obese and 18 normal-weight) aged 12-18 years who were candidates for maxillary first premolar extraction for Angle Class II malocclusion were included in the study. The two groups were formed according to World Health Organization guidelines. A normal-weight group (body mass index [BMI] 16-85%) and an obese group (BMI ≥ 95%). Gingival crevicular fluid samples were collected before, 24 hours after, and on the 7th, 14th, and 21st days after the application of the distalization force. Enzyme-linked immunosorbent assay was used to measure leptin, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and interleukin-6 (IL-6) levels in GCF samples. In addition to the recorded GCF sampling times, the amount of canine tooth movement was calculated using digital models obtained on the 28th day and 3rd month.
Results: Leptin, RANKL, OPG, and IL-6 levels were significantly higher in the obese group (P < 0.05). The digital model measurements displayed high rates of repeatability (ICC 0.990). The difference in the amount of tooth movement between groups was not statistically significant (P > 0.05).
Conclusions: Although obese and normal-weight individuals showed different biomarker levels during tooth movement, there were no significant differences in the amount of movement.
期刊介绍：
The Korean Journal of Orthodontics (KJO) is an international, open access, peer reviewed journal published in January, March, May, July, September, and November each year. It was first launched in 1970 and, as the official scientific publication of Korean Association of Orthodontists, KJO aims to publish high quality clinical and scientific original research papers in all areas related to orthodontics and dentofacial orthopedics. Specifically, its interest focuses on evidence-based investigations of contemporary diagnostic procedures and treatment techniques, expanding to significant clinical reports of diverse treatment approaches.
The scope of KJO covers all areas of orthodontics and dentofacial orthopedics including successful diagnostic procedures and treatment planning, growth and development of the face and its clinical implications, appliance designs, biomechanics, TMJ disorders and adult treatment. Specifically, its latest interest focuses on skeletal anchorage devices, orthodontic appliance and biomaterials, 3 dimensional imaging techniques utilized for dentofacial diagnosis and treatment planning, and orthognathic surgery to correct skeletal disharmony in association of orthodontic treatment.
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