Prevalence and concentration of aflatoxin M1 in milk and dairy products: an umbrella review of meta-analyses.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Health Pub Date : 2025-01-24 DOI:10.1093/inthealth/ihaf002

Abdolreza Sotoodeh Jahromi, Mohammad Jokar, Arman Abdous, Mohammad Hasan Rabiee, Farzad Heydari Bahman Biglo, Vahid Rahmanian

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引用次数: 0

Abstract

Background: Aflatoxin M1 (AFM1) is a derivative of aflatoxin B1 and a significant contaminant of milk and dairy products. In this study, we implemented an umbrella review of all existing systematic reviews and meta-analyzing studies to apprise and summarize the worldwide prevalence and level of AFM1 in milk and dairy products.

Methods: We conducted a systematic review of structured review and meta-analysis articles published in English until January 2024, with no time limit. Articles were sourced from reputable databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL and the Cochrane Database of Systematic Reviews. Relevant studies from Google Scholar were also included.

Results: The overall prevalence of AFM1 in all dairy products was 66.2% (95% CI 60.6 to 71.9%), with high heterogeneity (I²=99.7%, Q statistic=2221.03, p<0.0001). The prevalence for specific dairy products was as follows: raw milk, 64.8% (95% CI 60.9 to 68.7%); pasteurized milk, 88.7% (95% CI 81.6 to 95.7%); sterilized milk, 71.0% (95% CI 67.2 to 74.8%); ultra-high temperature processing (UHT) milk, 67.9% (95% CI 64.9 to 70.9%); yogurt, 58.8% (95% CI 42.5 to 75.1%); doogh, 17.2% (95% CI 13.9 to 20.5%); and cheese 49.8% (95% CI 47.8 to 51.9%). The overall mean concentration of AFM1 across all dairy products was 57.22 ng/kg (95% CI 46.95 to 67.49), with significant heterogeneity (I²=99.7%, Q statistic=2221.03, p<0.0001). Mean AFM1 levels (ng/kg) for each dairy product were as follows: raw milk, 52.51 (95% CI 40.96 to 64.05); pasteurized milk, 71.14 (95% CI 48.81 to 93.47); sterilized milk, 60.10 (95% CI 30.90 to 89.30); UHT milk, 82.57 (95% CI 35.30 to 129.85); yogurt, 46.74 (95% CI 24.27 to 69.21); and doogh, 41.60 (95% CI 32.60 to 50.60).

Conclusions: In total, these results highlight the importance of increasing the regulation of animal feed, reducing aflatoxin B1 (AFB1) in animal feed, and monitoring AFM1 in dairy products, particularly raw and heated milk.

查看原文本刊更多论文

牛奶和奶制品中黄曲霉毒素M1的流行和浓度：荟萃分析综述。

背景：黄曲霉毒素M1 （AFM1）是黄曲霉毒素B1的衍生物，是牛奶和乳制品中的重要污染物。在这项研究中，我们对所有现有的系统评价和荟萃分析研究进行了总括性回顾，以了解和总结牛奶和乳制品中AFM1的全球患病率和水平。方法：我们对2024年1月前发表的英文结构化综述和荟萃分析文章进行了系统综述，没有时间限制。文章来源于知名数据库，包括PubMed/MEDLINE、EMBASE、Scopus、Web of Science、CINAHL和Cochrane系统综述数据库。b谷歌Scholar的相关研究也被纳入。结果：所有乳制品中AFM1的总体流行率为66.2% (95% CI为60.6 ~ 71.9%)，具有较高的异质性（I²=99.7%，Q统计量=2221.03,p）。结论：加强动物饲料的调控，降低动物饲料中的黄曲霉毒素B1 (AFB1)，监测乳制品中AFM1的重要性，特别是原料奶和加热奶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.