Predicting child health with gut microbiome development trajectories

IF 20.5 1区生物学 Q1 MICROBIOLOGY

Nature Microbiology Pub Date : 2025-01-24 DOI:10.1038/s41564-024-01920-6

Douglas E. Johnson, Roshonda B. Jones

引用次数: 0

查看原文本刊更多论文

用肠道微生物群发育轨迹预测儿童健康

人体肠道微生物群在帮助消化、调节宿主免疫力、新陈代谢、抵御病原体和整体健康方面发挥着至关重要的作用。对于儿童来说，在生命的头两到三年里，肠道微生物群的发育是至关重要的，是决定一生健康结果的关键时期。尽管它很重要，但我们对婴儿肠道微生物群如何进化及其对未来健康的影响的理解仍然不完整。发展性肠道微生物组研究通常依赖于小规模或横断面研究，限制了我们追踪微生物群随时间变化或预测其对未来健康结果影响的能力。希克曼及其同事的研究使用16S rRNA基因测序和纵向统计模型来预测早期微生物群的发展轨迹，并将它们与生命最初5年的健康状况联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Microbiology Immunology and Microbiology-Microbiology

CiteScore

44.40

自引率

1.10%

发文量

226

期刊介绍： Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.