Fluorometric Turn Off Detection of Cu2+ and Pd2+ Ions Using 1-(Imidazo[5,1-a]isoquinolin-3-yl)naphthalen-2-ol

IF 3.2 4区 化学 Q2 CHEMISTRY, ANALYTICAL
Luminescence Pub Date : 2025-01-23 DOI:10.1002/bio.70104
Sandeep Kumar, Hitesh Phogat, Vadivelu Manivannan
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引用次数: 0

Abstract

The fused heterocycle 1-(imidazo[5,1-a]isoquinolin-3-yl)naphthalen-2-ol (LH) has been synthesized and characterized by spectroscopic methods. Probe LH upon irradiation with λex = 336 nm exhibited strong fluorescence with λem = 437 nm in MeOH/HEPES buffer (5 mM, pH = 7.4, 2:8, v/v). Upon adding several metal ions, the fluorescence intensity was quenched only by Cu2+ and Pd2+ ions. This fluorescence turn-off response by Cu2+ and Pd2+ ions was observed even in the coexistence of other metal ions and anions. From the Job's plot and mass spectra analysis, a 2:1 ratio of LH:M2+ was obtained, and the composition [Cu(L)2H2O] and [Pd(L)2] has been assigned. The detection limit for Cu2+ and Pd2+ ions was determined to be 0.24 and 0.35 μM, respectively, and workable pH window to be 4–10. The binding of LH to Cu2+ and Pd2+ resulted in red-shift in the UV–visible spectrum, which was supported by DFT/TDDFT calculations.

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来源期刊
Luminescence
Luminescence 生物-生化与分子生物学
CiteScore
5.10
自引率
13.80%
发文量
248
审稿时长
3.5 months
期刊介绍: Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.
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