PERspectives on circadian cell biology.

IF 5.4 2区生物学 Q1 BIOLOGY

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2025-01-23 DOI:10.1098/rstb.2023.0483

Andrei Mihut, John S O'Neill, Carrie L Partch, Priya Crosby

引用次数: 0

Abstract

Daily rhythms in the activities of PERIOD proteins are critical to the temporal regulation of mammalian physiology. While the molecular partners and genetic circuits that allow PERIOD to effect auto-repression and regulate transcriptional programmes are increasingly well understood, comprehension of the time-resolved mechanisms that allow PERIOD to conduct this daily dance is incomplete. Here, we consider the character and controversies of this central mammalian clock protein with a focus on its intrinsically disordered nature.This article is part of the Theo Murphy meeting issue 'Circadian rhythms in infection and immunity'.

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来源期刊

Philosophical Transactions of the Royal Society B: Biological Sciences 生物-生物学

CiteScore

11.80

自引率

1.60%

发文量

365

审稿时长

3 months

期刊介绍： The journal publishes topics across the life sciences. As long as the core subject lies within the biological sciences, some issues may also include content crossing into other areas such as the physical sciences, social sciences, biophysics, policy, economics etc. Issues generally sit within four broad areas (although many issues sit across these areas): Organismal, environmental and evolutionary biology Neuroscience and cognition Cellular, molecular and developmental biology Health and disease.