RXRs expression in skeletal muscle in relationship with insulin sensitivity in normal-weight and obese volunteers.

IF 1.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-01-17 eCollection Date: 2025-06-01 DOI:10.1007/s40200-024-01546-9

Róża Aleksandrowicz, Marek Strączkowski

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引用次数: 0

Abstract

Objectives: Retinoid X receptors (RXRs) are nuclear hormone receptors (NRs) functioning as transcription factors. There are three RXR isoforms: RXRA (NR2B1), RXRB (NR2B2), and RXRG (NR2B3). RXRs serve as master regulators of gene networks governing cell growth, differentiation, survival, and death. RXRs might affect insulin action, but very little data currently supports this relationship. The aim of the study was to analyze the relationship between the expression of RXRs in skeletal muscles and insulin sensitivity in young, normal-weight, overweight and obese people.

Methods: The research group consisted of 45 volunteers, 20 had normal body weight, 13 were overweight, and 12 were obese. Insulin sensitivity was measured with hyperinsulinemic-euglycemic clamp. Vastus lateralis muscle biopsies were taken before each clamp, and RXRs mRNA expression was analyzed.

Results: RXRA expression was lower in overweight, obese subjects in comparison with normal-weight volunteers (P = 0.003, P = 0.002, respectively). RXRB and RXRG expression did not differ between the groups. RXRA expression in muscle was positively correlated with insulin sensitivity (r = 0.49, P = 0.001). The relationship between muscle tissue RXRA and insulin sensitivity was independent of BMI (β = 0.35, P = 0.02).

Conclusions: Our results indicate that RXRA expression in skeletal muscle is linked to insulin sensitivity. The data suggest that muscle-associated RXRs may play a role in modulating insulin action.

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正常体重和肥胖志愿者骨骼肌中RXRs表达与胰岛素敏感性的关系

目的：类视黄醇X受体（Retinoid X receptor, RXRs）是具有转录因子功能的核激素受体。RXR有三种异构体：RXRA （NR2B1）、RXRB （NR2B2）和RXRG （NR2B3）。RXRs是控制细胞生长、分化、存活和死亡的基因网络的主要调控因子。RXRs可能会影响胰岛素的作用，但目前很少有数据支持这种关系。该研究的目的是分析年轻、正常体重、超重和肥胖人群骨骼肌中RXRs表达与胰岛素敏感性之间的关系。方法：研究小组由45名志愿者组成，其中正常体重20人，超重13人，肥胖12人。采用高胰岛素-正糖钳法测定胰岛素敏感性。每次钳夹前取股外侧肌活检，分析RXRs mRNA表达。结果：RXRA在超重、肥胖人群中的表达低于正常体重人群（P = 0.003, P = 0.002）。RXRB和RXRG的表达在各组间无差异。RXRA在肌肉中的表达与胰岛素敏感性呈正相关（r = 0.49, P = 0.001）。肌肉组织RXRA与胰岛素敏感性的关系与BMI无关（β = 0.35, P = 0.02）。结论：我们的研究结果表明RXRA在骨骼肌中的表达与胰岛素敏感性有关。数据表明，肌肉相关的RXRs可能在调节胰岛素作用中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.