Effects of ethylenediaminetetraacetic acid chelation for calcific band keratopathy on corneal topography assessed by fourier harmonic analysis.

IF 2.1 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI:10.1007/s10384-025-01160-z

Shoko Saito, Yumi Kusumi, Yoji Takano, Masaki Fukui, Masakazu Yamada

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引用次数: 0

Abstract

Purpose: Chemical chelation with ethylenediaminetetraacetic acid (EDTA) is an established treatment for calcific band keratopathy (CBK), whereas removal of calcium deposits from the subepithelial layer of the cornea may cause corneal irregularity. Using Fourier harmonic analysis, we analyzed the corneal topography in eyes with CBK treated by EDTA chelation.

Study design: Retrospective, single-center study.

Methods: This study included 42 eyes of 26 patients who underwent chemical chelation using EDTA for CBK at the Kyorin University Hospital. Clinical data included age, sex, refraction, visual acuity, operation records, and corneal topography. Corneal topography was evaluated by a TMS-5 Corneal Topographer, and 3.0- and 6.0-mm-diameter Fourier series harmonic analyses were performed. Refraction, visual acuity, and parameters of corneal topography were compared before surgery and at 1 and 4 weeks postoperatively.

Results: Visual acuity and refraction (spherical equivalent and astigmatism) did not significantly change at 4 weeks postoperatively. Fourier harmonic analysis revealed that there were no time serial changes in the spherical component and regular astigmatism in both 3.0- and 6.0-mm analyses. Asymmetry astigmatism, and high-order irregularity significantly increased at 1 week postoperatively but decreased at 4 weeks postoperatively, with no statistical differences compared with preoperative data.

Conclusion: The effects of EDTA treatment on the corneal shape and refraction are minimal, which is beneficial for maintaining visual function in patients with CBK.

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用傅立叶谐波分析评价乙二胺四乙酸螯合治疗钙化带性角膜病变对角膜形貌的影响。

目的：乙二胺四乙酸（EDTA）化学螯合是治疗钙化带角膜病（CBK）的一种既定治疗方法，而从角膜上皮下层去除钙沉积物可能导致角膜不规则。采用傅里叶谐波分析方法，分析了EDTA螯合治疗CBK的角膜地形图。研究设计：回顾性、单中心研究。方法：本研究包括在高丽大学医院使用EDTA进行化学螯合治疗CBK的26例患者的42只眼睛。临床资料包括年龄、性别、屈光、视力、手术记录和角膜地形图。通过TMS-5角膜地形仪评估角膜地形，并进行3.0和6.0 mm直径的傅立叶级数谐波分析。比较术前、术后1、4周屈光、视力及角膜地形图参数。结果：术后4周视力和屈光（球当量和散光）无明显变化。傅里叶调和分析表明，在3.0 mm和6.0 mm分析中，球面分量和规则散光没有时间序列变化。非对称散光、高阶不规则性在术后1周明显增加，术后4周明显减少，与术前比较无统计学差异。结论：EDTA治疗对CBK患者角膜形态和屈光度的影响很小，有利于维持患者的视功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.