Peri-Implant Epstein–Barr Virus (+) Mucocutaneous Ulcer in an Immunocompetent Patient: Case Report and Review of the Literature

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Implant Dentistry and Related Research Pub Date : 2025-01-17 DOI:10.1111/cid.13440

Irene Lafuente-Ibáñez de Mendoza, Pablo Aguirre-Echevarria, Tulio Mateo Silva-Soria, Francisco Javier Vallejo Aisa, Aitor Fernández de Larrinoa, José Manuel Aguirre-Urizar

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Abstract

Epstein–Barr virus (+) mucocutaneous ulcer (EBVMCU) is an uncommon benign lymphoproliferative lesion that develops in immunocompromised patients. We present a special case of EBVMCU located in the peri-implant mucosa and we review the oral cases published to date. An 88-year-old man with no medical history of interest was attended in the dental clinic due to an ulcerated tumor located in the peri-implant mucosa. The lesion showed an atypical lymphoid proliferation, positive for CD3, CD20, CD30, PAX-5, and MUM1. Positive EBV and favorable patient evolution confirmed the final diagnosis of EBVMCU. Oral EBVMCU reports related to immunosenescence mainly develop in the gingiva of advanced age patients. Our case highlights the importance to perform a complete clinicopathological study of all peri-implant lesions. Although most peri-implant pathologies are inflammatory-reactive disorders, sometimes they can also correspond to other entities.

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免疫功能正常患者种植体周围eb病毒（+）粘膜皮肤溃疡：病例报告和文献回顾

eb病毒（+）粘膜皮肤溃疡（EBVMCU）是一种罕见的良性淋巴增生性病变，发生在免疫功能低下的患者中。我们报告了一例位于种植体周围粘膜的EBVMCU的特殊病例，并回顾了迄今为止发表的口腔病例。一名88岁男性，无病史，因种植体周围粘膜溃疡性肿瘤就诊于牙科诊所。病变表现为非典型淋巴细胞增生，CD3、CD20、CD30、PAX-5和MUM1阳性。EBV阳性和有利的患者进化证实了EBVMCU的最终诊断。口腔EBVMCU与免疫衰老相关的报道主要发生在老年患者的牙龈。我们的病例强调了对所有种植体周围病变进行完整临床病理研究的重要性。虽然大多数种植体周围病变是炎症反应性疾病，但有时它们也可以与其他实体相对应。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.