A combination regimen of Intravitreal clindamycin with dexamethasone, systemic co-trimoxazole and steroids for macular Toxoplasma retinochoroiditis in immunocompetent cases.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-01-10 DOI:10.1097/IAE.0000000000004383

Sushree Satavasia, Akshay Mishra, Vishal Jadhav, Talluri Ronnie Abhishek, Anup Kelgaonkar, Anamika Patel, Soumyava Basu, Avinash Pathengay

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Abstract

Purpose: To study the role of intravitreal clindamycin with dexamethasone as an adjuvant to systemic co-trimoxazole and steroids in macular Toxoplasma retinochoroiditis.

Methods: Retrospective study of Toxoplasma retinochoroiditis cases from January 2014 to December 2021 treated with a combination of oral and intravitreal therapy in immunocompetent patients.

Results: 39 eyes of 39 patients were included in this study after meeting the inclusion criteria with the mean age of presentation being 25.25 years (± 9.30; range 4-52 years). Male preponderance with 61.53 % of males (n = 24) and 38.47% of females (n = 15) was observed. Active retinitis was unilateral in all eyes (20 right eyes; 19 left eyes). Five lines of improvement in vision acuity on ETDRS chart were noted at final visit. The location of retinitis was either foveal (n=24) or extrafoveal (n=15). The mean size of retinitis was 1.24 ± 0.70-disc diameter. The mean number of injections given was 1.79 with a mean interval of 1.39 weeks.

Conclusions: Intravitreal clindamycin with dexamethasone when used as an adjunct to systemic therapy showed resolution of retinitis in all cases with visual improvement.

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玻璃体内克林霉素联合地塞米松、全身复方新诺明和类固醇治疗免疫功能正常的黄斑性视网膜脉络膜炎

目的：探讨玻璃体内注射克林霉素联合地塞米松辅助全身复方新诺明和类固醇治疗黄斑弓形虫视网膜脉络膜炎的作用。方法：回顾性研究2014年1月至2021年12月免疫功能正常的视网膜脉络膜炎患者口服+玻璃体内联合治疗的弓形虫病例。结果：39例患者39只眼符合纳入标准，平均出现年龄为25.25岁(±9.30；范围4-52年)。男性优势，男性占61.53% (n = 24)，女性占38.47% （n = 15）。所有眼均为单侧活动性视网膜炎(右眼20只；19左眼)。在最后一次访问时，ETDRS表上的视力改善有五条线。视网膜炎发生在视网膜中央凹（n=24）或视网膜中央凹外（n=15）。视网膜炎的平均大小为1.24±0.70椎间盘直径。平均注射次数为1.79次，平均间隔时间为1.39周。结论：玻璃体内注射克林霉素和地塞米松作为全身治疗的辅助，所有患者的视力都得到改善，视网膜炎得到缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.