Role of macrophage polarization in diabetic foot ulcer healing: A bibliometric study.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-01-15 DOI:10.4239/wjd.v16.i1.99755

You-Wen Zhang, Lei Sun, Yan-Nan Wang, Shi-Yu Zhan

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引用次数: 0

Abstract

Background: Diabetic foot ulcers (DFUs) are a significant contributor to disability and mortality in diabetic patients. Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing. However, the complex mechanism, the difficulty in clinical translation, and the large heterogeneity present significant challenges. Hence, this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU healing.

Aim: To examine the relevant literature on macrophage polarization in DFU healing.

Methods: A bibliometric analysis was conducted using the Web of Science database. Relevant literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software (VOSviewer and CiteSpace) and bibliometric online platforms. The obtained literature was then subjected to visualization and analysis of different countries/regions, institutions, journals, authors, and keywords to reveal the research's major trends and focus.

Results: The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023, especially in the latter period. Chinese researchers were the most prolific in this field, with 217 publications, while American researchers had been engaged in this field for a longer period. Qian Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this field. Shanghai Jiao Tong University was the institution with the most publications (27). The keywords "bone marrow", "adjustment, replacement, response, tissue repair", and "activation, repair, differentiation" appeared more frequently. The study of macrophage polarization in DFU healing focused on the regulatory mechanism, gene expression, and other aspects.

Conclusion: This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polarization in DFU healing from 2013 to 2023 in the Web of Science Core Collection database. The key hotspots in this field mainly include the regulation of macrophage activation, gene expression, wound tissue repair, and new wound materials. This study provides references for future research directions.

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巨噬细胞极化在糖尿病足溃疡愈合中的作用：文献计量学研究。

背景：糖尿病足溃疡（DFUs）是糖尿病患者致残和死亡的重要因素。巨噬细胞极化和功能调控是DFU愈合领域的研究热点，具有治疗潜力。然而，其复杂的机制、临床翻译的困难以及巨大的异质性都带来了重大挑战。因此，本研究旨在综合分析巨噬细胞极化与DFU愈合的研究发表现状及趋势。目的：查阅巨噬细胞极化在DFU愈合中的相关文献。方法：利用Web of Science数据库进行文献计量学分析。利用文献可视化分析软件（VOSviewer和CiteSpace）和文献计量学在线平台，从Web of Science Core Collection数据库中检索2013 - 2023年的相关文献。然后对所获得的文献进行可视化和不同国家/地区、机构、期刊、作者和关键词的分析，以揭示研究的主要趋势和重点。结果：2013 - 2023年，巨噬细胞极化在DFU愈合中的作用的论文数量迅速增加，尤其是后期。中国研究人员在这一领域的研究成果最多，发表了217篇论文，而美国研究人员从事这一领域的时间更长。南京鼓楼医院的钱谭和南京大学的钱丁率先在这一领域发表论文。上海交通大学是发表论文最多的院校（27篇）。关键词“骨髓”、“调节、替代、应答、组织修复”、“激活、修复、分化”出现频率较高。巨噬细胞极化在DFU愈合中的研究主要集中在调控机制、基因表达等方面。结论：本研究通过文献计量学方法揭示了Web of Science Core Collection数据库2013 - 2023年巨噬细胞极化在DFU愈合领域的研究趋势和发展趋势。该领域的重点热点主要包括巨噬细胞活化调控、基因表达、创面组织修复、创面新材料等。本研究为今后的研究方向提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.