The dual function of autophagy in doxorubicin-induced cardiotoxicity: Mechanism and natural products

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2025-02-01 DOI:10.1016/j.semcancer.2025.01.004

Nannan Tan , Hanwen Luo , Weili Li , Guanjing Ling , Yan Wei , Wei Wang , Yong Wang

引用次数: 0

Abstract

Doxorubicin (DOX) is an anthracycline antitumor drug discovered in 1969, which can care for leukemia, breast cancer, lymphoma, and sarcoma. However, cardiotoxicity induced by DOX seriously limits its clinical value. The etiopathogenesis and therapeutic strategies are not unified. Autophagy is a critical mechanism in the progression of DOX-induced cardiotoxicity (DIC), autophagy intervention is a potential therapeutic strategy for DIC. Natural product has been considered as a complementary and alternative approach to treat cardiovascular disease. In this review, we summarize the pathology of autophagy in DIC and the natural products for DIC therapy.

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自噬在阿霉素诱导的心脏毒性中的双重功能：机制和天然产物。

多柔比星（DOX）是1969年发现的一种蒽环类抗肿瘤药物，可治疗白血病、乳腺癌、淋巴瘤和肉瘤。然而，DOX的心脏毒性严重限制了其临床应用价值。发病机制和治疗策略不统一。自噬是dox诱导的心脏毒性（DIC）发生的重要机制，自噬干预是治疗DIC的一种潜在的治疗策略。天然产物已被认为是治疗心血管疾病的补充和替代方法。本文就DIC的自噬病理及治疗DIC的天然产物作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.