Emerging role of adaptive immunity in diabetes-induced cognitive impairment: from the periphery to the brain.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolic brain disease Pub Date : 2025-01-16 DOI:10.1007/s11011-025-01532-x

Genhui Yang, Runtao Su, Jie Bu, Ying Li, Xueling Lin, Jiahui Jin, Yanjun Zhang, Pengwei Zhuang, Hong Guo, Qingsheng Yin

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Abstract

Diabetic cognitive impairment (DCI) is a central nervous system complication induced by peripheral metabolic dysfunction of diabetes mellitus. Cumulative studies have shown that neuro-immune crosstalk is involved in the pathological progression of DCI. However, current studies mostly focus on the interaction between innate immunity cells and neurons, while ignoring the role of adaptive immunity cells in DCI. Notably, recent studies have revealed adaptive immune cells are involved in cognitive development and the progression of neurodegenerative diseases. Equally important, accumulated past studies have also shown that diabetic patients experience imbalanced peripheral adaptive immune homeostasis and disrupted transmission of adaptive immune cells to the central system. Therefore, this review first updated the cognitive mechanism of adaptive immune regulation, and then summarized the contribution of adaptive immunity to DCI from the aspects of peripheral adaptive immune homeostasis, transmission pathways, and brain tissue infiltration. Furthermore, we also summarized the potential of anti-diabetic drugs to regulate adaptive immunity, and looked forward to the potential value of regulatory adaptive immunity in the prevention and treatment of DCI, to provide a new strategy for the prevention and treatment of DCI.

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适应性免疫在糖尿病引起的认知障碍中的新作用：从外周到大脑。

糖尿病认知障碍（DCI）是由糖尿病外周代谢障碍引起的中枢神经系统并发症。累积研究表明，神经免疫串扰参与了DCI的病理进展。然而，目前的研究大多集中在先天免疫细胞与神经元的相互作用上，而忽视了适应性免疫细胞在DCI中的作用。值得注意的是，最近的研究表明适应性免疫细胞参与认知发育和神经退行性疾病的进展。同样重要的是，过去积累的研究也表明，糖尿病患者外周适应性免疫稳态失衡，适应性免疫细胞向中枢系统的传输中断。因此，本文首先对适应性免疫调节的认知机制进行了更新，然后从外周适应性免疫稳态、传递途径和脑组织浸润等方面综述了适应性免疫对DCI的贡献。此外，我们还总结了抗糖尿病药物调节适应性免疫的潜力，并展望了调节性适应性免疫在预防和治疗DCI中的潜在价值，为预防和治疗DCI提供新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolic brain disease 医学-内分泌学与代谢

CiteScore

5.90

自引率

5.60%

发文量

248

审稿时长

6-12 weeks

期刊介绍： Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.