Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Medicine Pub Date : 2025-01-21 DOI:10.1186/s10020-025-01074-z

Syed Faizan Mehdi, Muhammad Hamza Qureshi, Salman Pervaiz, Karishma Kumari, Edwin Saji, Mahnoor Shah, Ahmad Abdullah, Kamran Zahoor, Hafiza Amna Qadeer, Disha Kumari Katari, Christine Metz, Lopa Mishra, Derek LeRoith, Kevin Tracey, Michael J Brownstein, Jesse Roth

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引用次数: 0

Abstract

Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortisolemia is evident throughout the acute phase, along with changes in the hypothalamic pituitary thyroid (HPT) axis, growth hormone-IGF-1 axis, insulin-glucose axis, leptin, catecholamines, renin angiotensin aldosterone axis, ghrelin, glucagon, hypothalamic pituitary gonadal (HGA) axis, and fibroblast growth factor-21. These changes and metabolic alterations constitute the overall response to infection in sepsis. Further research is essential to look into the hormonal changes that occur during sepsis, not only to understand their potential relevance in therapy but also because they may serve as prognostic indicators.

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内分泌和代谢改变对全身性炎症和败血症的反应：综述文章。

严重的脓毒症与危及生命的多器官功能障碍有关。内分泌功能紊乱，几种激素通路发生改变。它经常与下丘脑-垂体-肾上腺轴（HPA）功能障碍有关。皮质醇升高或皮质醇血症在整个急性期都很明显，同时伴有下丘脑垂体-甲状腺（HPT）轴、生长激素- igf -1轴、胰岛素-葡萄糖轴、瘦素、儿茶酚胺、肾素血管紧张素醛固酮轴、生长素、胰高血糖素、下丘脑垂体-性腺（HGA）轴和成纤维细胞生长因子-21的变化。这些变化和代谢改变构成了败血症感染的总体反应。进一步研究脓毒症期间发生的激素变化是必要的，不仅要了解它们在治疗中的潜在相关性，而且因为它们可以作为预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Medicine 医学-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

137

审稿时长

1 months

期刊介绍： Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.