Co-infection of Dengue and hepatitis A virus among pediatric population: A study from a tertiary care center in central India during 2022-2023.

IF 0.8 4区医学 Q4 INFECTIOUS DISEASES

Journal of Vector Borne Diseases Pub Date : 2025-01-18 DOI:10.4103/JVBD.JVBD_188_24

Rajeev Kumar Jain, Rakesh Shrivastava, Garima Kapoor, Deepti Chaurasia, Kamlesh Kumar Ahirwar, Ankita Agarwal

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引用次数: 0

Abstract

Background objectives: Co-infection of dengue virus and acute hepatitis A virus in paediatric population is a major health concern in endemic countries. This cross sectional retrospective study was conducted to evaluate the prevalence of hepatitis A virus among the clinically dengue suspected paediatric cases presented at our tertiary care centre during the two-year period (2022-2023).

Methods: A total of 747 dengue suspected paediatric clinical specimens were included in this study. Serological diagnosis of DENV and HAV was done using Dengue IgM capture ELISA kit and anti-HAV IgM ELISA kits.

Results: Out of the 747 dengue suspected paediatric patients, 245 (32.8%) were seropositive for either DENV, HAV, or both viruses and among these 135 (18.07%) were positive for DENV, 110 (14.72%) were positive for HAV, 22 (2.94%) were co-infected with both DENV and HAV. Further, among DENV seronegative cases, 88 (11.78%) clinical samples were found to be HAV positive. Among all the age groups, the highest prevalence of DENV and HAV was observed in 6-10 yrs. The monsoon season observed the highest number of seropositive cases compared to winter season and summer seasons. Fever was found to be most prevalent clinical symptom followed by nausea/vomiting and stomach discomfort.

Interpretation conclusion: This study underlines the significance of differential diagnosis for the detection of concurrently transmitted viral diseases during the common seasons in the endemic areas. Diagnostic challenges like misdiagnosis events can be solved by advising differential diagnosis especially in paediatric cases.

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儿科人群中登革热和甲型肝炎病毒的合并感染：2022-2023年印度中部三级保健中心的一项研究

背景目的：登革热病毒和急性甲型肝炎病毒在儿科人群中的合并感染是流行国家的一个主要卫生问题。本横断面回顾性研究旨在评估两年间（2022-2023年）在三级保健中心就诊的临床登革热疑似儿科病例中甲型肝炎病毒的流行情况。方法：对747例疑似登革热患儿临床标本进行分析。采用登革热IgM捕获ELISA试剂盒和抗HAV IgM ELISA试剂盒对DENV和HAV进行血清学诊断。结果：747例登革热疑似患儿中，DENV、HAV或两者血清阳性245例（32.8%），其中DENV阳性135例（18.07%），HAV阳性110例（14.72%），DENV和HAV合并感染22例（2.94%）。DENV血清阴性病例中，HAV阳性病例88例（11.78%）。在所有年龄组中，DENV和HAV的最高流行年龄为6-10岁。与冬季和夏季相比，季风季节的血清阳性病例最多。发烧是最常见的临床症状，其次是恶心/呕吐和胃部不适。结论：本研究强调了在流行地区常见季节鉴别诊断同时传播的病毒性疾病的意义。诊断方面的挑战，如误诊事件，可以通过建议鉴别诊断来解决，特别是在儿科病例中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vector Borne Diseases INFECTIOUS DISEASES-PARASITOLOGY

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： National Institute of Malaria Research on behalf of Indian Council of Medical Research (ICMR) publishes the Journal of Vector Borne Diseases. This Journal was earlier published as the Indian Journal of Malariology, a peer reviewed and open access biomedical journal in the field of vector borne diseases. The Journal publishes review articles, original research articles, short research communications, case reports of prime importance, letters to the editor in the field of vector borne diseases and their control.