Relationships Between the Infrapatellar Fat Pad and Patellofemoral Joint Osteoarthritis Differ With Body Mass Index and Sex

IF 2.1 3区 医学 Q2 ORTHOPEDICS
J. G. Wagner, L. Chen, F. Jiang, E. Nedley, Z. Akkaya, Chotigar Ngarmsrikan, T. M. Link, S. Majumdar, K. H. Collins, R. B. Souza
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Abstract

The role of the infrapatellar fat pad (IPFP) in knee osteoarthritis is not understood. This study aimed to identify relationships between MRI-based signal abnormalities in the IPFP and measures of structural pathology and symptom severity in PFJOA, as well as investigate the influence of obesity and sex on these relationships. Seventy participants (ages 28–80) with isolated PFJOA underwent bilateral knee MRI scan acquisitions and completed the Knee Injury and Osteoarthritis Outcome Score (KOOS). MR images were scored for abnormal IPFP area and signal intensity, joint effusion, synovial proliferation, and patellar and trochlear cartilage damage. Repeated measures correlations were performed to assess associations between abnormal area and signal of IPFP and PFJOA pathology and KOOS, respectively. Associations were interrogated across weight-based groups based on BMI and sex-based groups. Between abnormal IPFP and PFJOA pathology, we observed no significant associations. Between abnormal IPFP and patient-reported outcomes, we observed weak to moderate significant negative associations between the size of the abnormal IPFP area and all KOOS subscales. In a sex-based analysis of IPFP and KOOS associations, we observed significant moderate negative correlations between IPFP and KOOS scores across all subcategories in female participants. In male participants, abnormal IPFP was not associated with KOOS scores. The IPFP is significantly related to PFJOA patient-reported pain and function, and this correlation is stronger in high-risk OA groups. 

髌下脂肪垫与髌股关节骨性关节炎的关系随体重指数和性别的不同而不同。
髌下脂肪垫(IPFP)在膝关节骨关节炎中的作用尚不清楚。本研究旨在确定IPFP中基于mri的信号异常与PFJOA的结构病理和症状严重程度之间的关系,并探讨肥胖和性别对这些关系的影响。70名患有孤立性PFJOA的参与者(年龄28-80岁)接受了双侧膝关节MRI扫描,并完成了膝关节损伤和骨关节炎结局评分(oos)。mri图像对IPFP异常面积和信号强度、关节积液、滑膜增生、髌骨和滑车软骨损伤进行评分。重复测量相关性分别评估IPFP和PFJOA病理异常区域和信号与kos之间的关系。研究人员对体重组和性别组之间的关联进行了调查。在IPFP异常和PFJOA病理之间,我们没有观察到明显的关联。在IPFP异常与患者报告的结果之间,我们观察到IPFP异常区域的大小与所有oos亚量表之间存在弱至中度显著负相关。在一项基于性别的IPFP和KOOS关联分析中,我们观察到女性参与者的IPFP和KOOS评分在所有子类别中存在显著的中度负相关。在男性参与者中,IPFP异常与KOOS评分无关。IPFP与PFJOA患者报告的疼痛和功能显著相关,这种相关性在高风险OA组中更强。
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来源期刊
Journal of Orthopaedic Research®
Journal of Orthopaedic Research® 医学-整形外科
CiteScore
6.10
自引率
3.60%
发文量
261
审稿时长
3-6 weeks
期刊介绍: The Journal of Orthopaedic Research is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.
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