Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis.

IF 13.3 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of Clinical Investigation Pub Date : 2025-01-16 DOI:10.1172/JCI188538

Yoshiaki Yasumizu, David A Hafler

引用次数: 0

Abstract

How are autoreactive T cells induced and regulated in patients with autoimmune disease? This question lies at the core of understanding autoimmune disease pathologies, yet it has remained elusive due to host variability and the complexity of the immune system. In this issue of the JCI, Kramer and colleagues used autoimmune hepatitis (AIH) as a model to explore the maintenance of autoreactive CD4+ T cells specific to O-phosphoseryl-tRNA:selenocysteine tRNA synthase (SepSecS). The findings provide insight into the interaction between T cells and B cells in AIH pathogenesis that may reflect a shared mechanism among other autoimmune diseases.

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阐明自身反应性T细胞和B细胞在自身免疫性肝炎中的作用。

自身免疫性疾病患者如何诱导和调节自身反应性T细胞？这个问题是理解自身免疫性疾病病理的核心，但由于宿主的可变性和免疫系统的复杂性，它仍然难以捉摸。在这一期的JCI中，Kramer及其同事以自身免疫性肝炎（AIH）为模型，探讨了对o -磷酸丝氨酸-tRNA：硒代半胱氨酸tRNA合成酶（SepSecS）特异性的自身反应性CD4+ T细胞的维持。这些发现为了解AIH发病机制中T细胞和B细胞之间的相互作用提供了见解，这可能反映了其他自身免疫性疾病的共同机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Investigation 医学-医学：研究与实验

CiteScore

24.50

自引率

1.30%

发文量

1034

审稿时长

2 months

期刊介绍： The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.