The Added Value of Apparent Diffusion Coefficient and Histogram Analysis in Assessing Treatment Response of Locally Advanced Cervical Cancer.

IF 1 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Computer Assisted Tomography Pub Date : 2025-01-01 Epub Date: 2024-11-13 DOI:10.1097/RCT.0000000000001642

Gehad A Saleh, Basma A Elged, Manal M Saleh, Amany Hassan, Rasha Karam

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引用次数: 0

Abstract

Objective: The aim of the study is to assess the diagnostic performance of quantitative analysis of diffusion-weighted imaging in assessing treatment response in cervical cancer patients.

Methods: A retrospective analysis was done for 50 patients with locally advanced cervical cancer who received concurrent chemoradiotherapy and underwent magnetic resonance imaging and diffusion-weighted imaging. Treatment response was classified into 4 categories according to RECIST criteria 6 months after therapy completion. Apparent diffusion coefficient (ADC) values were measured using both region of interest (ROI) ADC and whole lesion (WL) ADC histogram for all cases at both baseline pretreatment and posttreatment Magnetic resonance imaging studies. Changes in ADC values were calculated and compared between groups.

Results: The percentage change of ROI-ADCmean at a cutoff value of >20 had excellent discrimination of responders versus nonresponders, while the percentage change of WL-ADCmean, ADCmin, and ADCmax at cutoff values of >12.5, >35.8, and > 19.6 had acceptable discrimination of responders versus nonresponders. Logistic regression analysis revealed that only baseline WL ADCmin was a statistically significant independent predictor of response. Cancer cervix patients with baseline ADCmin < or equal to 0.73 have 12.1 times higher odds of exhibiting a response.

Conclusions: The percentage change of ROI-ADCmean and WL histogram ADCmean values after concurrent chemoradiotherapy can predict response. Pretreatment WL histogram ADCmin was a statistically significant independent predictor of posttherapy response.

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表观扩散系数的附加价值及直方图分析在评价局部晚期宫颈癌治疗疗效中的应用。

目的：探讨弥散加权成像定量分析在评价宫颈癌患者治疗反应中的诊断价值。方法：回顾性分析50例局部晚期宫颈癌患者行同步放化疗并行磁共振和弥散加权成像的临床资料。治疗结束后6个月，根据RECIST标准将治疗反应分为4类。采用感兴趣区域（ROI） ADC和全病变（WL） ADC直方图测量所有病例在基线预处理和治疗后的磁共振成像研究中的表观扩散系数（ADC）值。计算并比较各组ADC值的变化。结果：在截断值b>0时，ROI-ADCmean的百分比变化对应答者和无应答者具有极好的区别，而在截断值b>2.5、b>5.8和b>9.6时，WL-ADCmean、ADCmin和ADCmax的百分比变化对应答者和无应答者具有可接受的区别。Logistic回归分析显示，只有基线WL ADCmin是有统计学意义的反应独立预测因子。基线ADCmin <或等于0.73的宫颈癌患者表现出应答的几率高出12.1倍。结论：同步放化疗后ROI-ADCmean和WL直方图ADCmean的百分比变化可预测疗效。预处理WL直方图ADCmin是治疗后反应的有统计学意义的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Computer Assisted Tomography 医学-核医学

CiteScore

2.50

自引率

0.00%

发文量

230

审稿时长

4-8 weeks

期刊介绍： The mission of Journal of Computer Assisted Tomography is to showcase the latest clinical and research developments in CT, MR, and closely related diagnostic techniques. We encourage submission of both original research and review articles that have immediate or promissory clinical applications. Topics of special interest include: 1) functional MR and CT of the brain and body; 2) advanced/innovative MRI techniques (diffusion, perfusion, rapid scanning); and 3) advanced/innovative CT techniques (perfusion, multi-energy, dose-reduction, and processing).