Non-coding RNAs participate in interactions between senescence and gastrointestinal cancers.

IF 2.8 3区 生物学 Q2 GENETICS & HEREDITY
Frontiers in Genetics Pub Date : 2025-01-03 eCollection Date: 2024-01-01 DOI:10.3389/fgene.2024.1461404
Zhao-Zhe Liu, Fa-He Ji, Ying Piao
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Abstract

Relationships between cellular senescence and gastrointestinal cancers have gained prominence in recent years. The currently accepted theory suggests that cellular senescence and cancer occurrence exhibit "double-edged sword" effects. Cellular senescence is related to cancer via four "meta-hallmarks" i.e., genomic instability, epigenetic alterations, chronic inflammation, and dysbiosis, along with two "antagonistic hallmarks" i.e., telomere attrition and stem cell exhaustion. These relationships are characterized by both agonistic and antagonistic elements, but the existence of an intricate dynamic balance remains unknown. Non-coding RNAs (ncRNAs) have vital roles in post-transcriptional regulation, but how they participate in agonistic and antagonistic relationships between cellular senescence and gastrointestinal cancers remains to be fully investigated. In this article, we systematically review how ncRNAs (including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circularRNAs (circRNAs)) participate in interactions between cellular senescence and gastrointestinal cancers. Our aim is to elucidate a triangular relationship between "ncRNAs-senescence-gastrointestinal cancers" which considered these three elements as an equal important standing. We are keen to identify prognostic or therapeutic targets for gastrointestinal cancers from, i.e., aging-related ncRNAs, or discover novel strategies to treat and manage in the elderly. We seek to clarify complex relationships where ncRNAs participate in "senescence-gastrointestinal cancers" interactions.

非编码rna参与衰老和胃肠道癌症之间的相互作用。
近年来,细胞衰老与胃肠道癌症之间的关系日益突出。目前公认的理论认为,细胞衰老和癌症的发生表现出“双刃剑”效应。细胞衰老通过四个“元标志”(基因组不稳定、表观遗传改变、慢性炎症和生态失调)以及两个“拮抗标志”(端粒损耗和干细胞衰竭)与癌症相关。这些关系的特点是既激动又对抗的因素,但一个复杂的动态平衡的存在仍然未知。非编码rna (ncRNAs)在转录后调控中发挥着重要作用,但它们如何参与细胞衰老和胃肠道癌症之间的激动和拮抗关系仍有待充分研究。在本文中,我们系统地回顾了ncRNAs(包括microRNAs (miRNAs), long ncRNAs (lncRNAs)和circular arrnas (circRNAs))如何参与细胞衰老和胃肠道癌症之间的相互作用。我们的目的是阐明“ncrna -衰老-胃肠道癌症”之间的三角关系,认为这三个因素具有同等重要的地位。我们热衷于从衰老相关的ncrna中确定胃肠道癌症的预后或治疗靶点,或发现治疗和管理老年人的新策略。我们试图澄清ncrna参与“衰老-胃肠道癌症”相互作用的复杂关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Genetics
Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
5.50
自引率
8.10%
发文量
3491
审稿时长
14 weeks
期刊介绍: Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.
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