Effects of basic type of intermittent exotropia on myopic shift in children: a 12-month observational study.

IF 2.1 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2025-01-06 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1513062

Jing-Xin Li, Xiang-Xiang Liu, Jie Hao, Hui-Xin Li, Qiong-Yue Zhang, Yi-Yang Zhao, Yu-Meng Wang, Lei Li, Jing Fu

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引用次数: 0

Abstract

Background: To investigate the effect of basic intermittent exotropia (IXT) on myopic shift in children during 12-month follow-up.

Methods: 165 children aged 4-15 years were recruited prospectively in this study and divided into 3 groups: Group A, consisted of 64 patients with basic IXT without surgery; Group B, consisted of 51 patients 1-month after IXT-corrected surgery; and Group C, consisted of 50 patients without any form of strabismus. All patients underwent assessments of spherical equivalent (SE), axial length (AL), exodeviation, and binocular function relating to accommodation and convergence. Examinations were conducted at baseline and 12-month. SE and AL changes were compared among groups. Univariate and multivariate linear analyses were employed to investigate the association between myopic shift and IXT, as well as other clinical parameters.

Results: Three groups showed comparable ages, genders and SEs at baseline (all P > .05). During 12-month follow-up, the rate of myopic shift varied among groups. Significant differences in SE progression (P = .006) and AL elongation (P = .014) between Group A and Group C were observed. Although SE progression and AL elongation in Group B were less than Group A, no significant differences were found (P = .125; P = .038). In the multivariate analysis, increases in exodeviation angle were significantly associated with both SE progression (β = 0.010, P = .041) and AL elongation (β = -0.005, P = .026). Each one prism diopter increase in the exodeviation angle was correlated with a 0.01D SE progression and a 0.005 mm AL elongation.

Conclusions: Children with basic IXT exhibited faster myopia shift compared to those without strabismus. Although surgical correction of strabismus appeared to slow this process, the effect was not statistically significant. Furthermore, greater increase in exodeviation angle was associated with higher rate of SE progression and AL elongation.

Trial registration: The study was approved by the Ethics Committee of Beijing TongRen Hospital (approved number: TRECKY2020-142, approved date: 2020.10.30).

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基础型间歇性外斜视对儿童近视移位的影响：一项为期12个月的观察研究。

背景：通过12个月的随访，探讨原发性间歇性外斜视（IXT）对儿童近视移位的影响。方法：本研究前瞻性招募4-15岁儿童165例，分为3组：A组，64例基础IXT，未手术；B组：51例患者在ixt矫正手术后1个月；C组50例无任何形式斜视。所有患者均接受了球形当量（SE）、轴长（AL）、外偏和与调节和收敛相关的双眼功能的评估。在基线和12个月时进行检查。比较各组间SE、AL的变化。采用单因素和多因素线性分析探讨近视移位与IXT及其他临床参数的关系。结果：三组在基线时年龄、性别和社会地位相当（P < 0.05）。在12个月的随访中，各组的近视转移率有所不同。A组与C组在SE进展（P = 0.006）和AL延伸（P = 0.014）方面差异有统计学意义。虽然B组SE进展和AL延伸率低于A组，但差异无统计学意义(P = 0.125；p = .038)。在多变量分析中，外偏角的增加与SE进展（β = 0.010, P = 0.041）和AL延伸（β = -0.005, P = 0.026）显著相关。外偏角每增加1个棱镜屈光度与0.01D SE位移和0.005 mm AL伸长相关。结论：与无斜视的儿童相比，基础IXT儿童的近视转移速度更快。虽然斜视的手术矫正似乎减缓了这一过程，但效果没有统计学意义。此外，较大的外偏角增加与较高的SE进展率和AL延伸率相关。试验注册：本研究经北京同仁医院伦理委员会批准（批准号：TRECKY2020-142，批准日期：2020.10.30）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.