Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-01-07 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1493186

Guanying Yao, Xianchao Dou, Xiaozhu Chen, Haolin Qi, Jianling Chen, Peiwei Wu, Jialu Li, Shuang Liang, Zhongjiang Han, Shun Bai, Xu Hu

{"title":"Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation.","authors":"Guanying Yao, Xianchao Dou, Xiaozhu Chen, Haolin Qi, Jianling Chen, Peiwei Wu, Jialu Li, Shuang Liang, Zhongjiang Han, Shun Bai, Xu Hu","doi":"10.3389/fendo.2024.1493186","DOIUrl":null,"url":null,"abstract":"Objective: Several male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.Method: A total of 1485 participants were recruited from a university hospital between April 2020 and August 2022. Six hundred and thirtyfour men from couples with RPL were assigned to the case group, while 851 men from couple without RPL who underwent fertile evaluation were assigned to the control group. Semen parameters including sperm DNA fragmentation, were assessed.Results: No statistically significant differences in semen parameters, sperm kinematics and DFI were observed between the case group and the control group. A higher proportion of men in the case group had a DFI > 30% compared to those in the control group; however, this difference was not statistically significant. Restricted cubic spline analysis revealed no significant non-linear relationships between continuous DFI and risk of RPL.Conclusion: Our study indicates that there is no significant relationship between DFI and RPL risk. Further prospective studies are needed to explore the impact of DFI on fertility outcomes in couples experiencing RPL.","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1493186"},"PeriodicalIF":3.9000,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11746017/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fendo.2024.1493186","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Several male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.

Method: A total of 1485 participants were recruited from a university hospital between April 2020 and August 2022. Six hundred and thirtyfour men from couples with RPL were assigned to the case group, while 851 men from couple without RPL who underwent fertile evaluation were assigned to the control group. Semen parameters including sperm DNA fragmentation, were assessed.

Results: No statistically significant differences in semen parameters, sperm kinematics and DFI were observed between the case group and the control group. A higher proportion of men in the case group had a DFI > 30% compared to those in the control group; however, this difference was not statistically significant. Restricted cubic spline analysis revealed no significant non-linear relationships between continuous DFI and risk of RPL.

Conclusion: Our study indicates that there is no significant relationship between DFI and RPL risk. Further prospective studies are needed to explore the impact of DFI on fertility outcomes in couples experiencing RPL.

查看原文本刊更多论文

精子DNA断裂指数与复发性妊娠丢失之间的关系：来自1485名接受生育评估的参与者的结果。

目的：一些男性因素被报道在复发性妊娠丢失（RPL）中起作用。本研究旨在探讨精液参数、精子DNA碎片指数（DFI）与RPL之间的关系。方法：于2020年4月至2022年8月从某大学医院招募1485名参与者。634名患有生殖道不孕的男性被分配到病例组，而851名接受生殖道不孕评估的非生殖道不孕的男性被分配到对照组。评估精液参数，包括精子DNA碎片。结果：病例组与对照组精液参数、精子运动学、DFI差异无统计学意义。与对照组相比，病例组中男性DFI的比例更高，为30%；然而，这种差异在统计学上并不显著。限制三次样条分析显示，连续DFI与RPL风险之间没有显著的非线性关系。结论：本研究提示DFI与RPL风险无显著相关。需要进一步的前瞻性研究来探讨DFI对RPL夫妇生育结果的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.