Five new bisabolane-type sesquiterpenoids with oxygen-containing heterocyclic systems from Curcuma longa.

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-17 DOI:10.1016/j.fitote.2025.106399

Ou Dai, Guang-Xu Wu, Hong-Zhen Shu, Cheng Peng, Fei Liu, Liang Xiong

引用次数: 0

Abstract

Five new bisabolane-type sesquiterpenoids (1-5) were isolated from the rhizomes of Curcuma longa, and all of them were oxygen-containing heterocyclic compounds. The structures of the compounds were elucidated using comprehensive spectroscopic techniques, and their absolute configurations were confirmed through electronic circular dichroism (ECD) calculations. All of the compounds were evaluated for their vasorelaxant and anti-inflammatory activities. The results showed that only compound 4 exhibited a vasorelaxant effect against KCl-induced contraction of rat aortic rings, and it achieved a diastolic ratio that exceeded 25 % at a concentration of 25 μM.

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姜黄含氧杂环体系中五个新的双abolane型倍半萜类化合物。

从姜黄根茎中分离到5个新的双abolane型倍半萜类化合物（1 ~ 5），均为含氧杂环化合物。利用综合光谱技术对化合物的结构进行了分析，并通过电子圆二色性（ECD）计算确定了化合物的绝对构型。所有化合物的血管松弛和抗炎活性进行了评估。结果表明，只有化合物4对kcl诱导的大鼠主动脉环收缩具有血管松弛作用，在浓度为25 μM时，其舒张比超过25 %。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.