Sometimes Small Is Beautiful: Discovery of the Janus Kinases (JAK) and Signal Transducer and Activator of Transcription (STAT) Pathways and the Initial Development of JAK Inhibitors for IBD Treatment.

IF 2.5 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jonathan D Kaunitz
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引用次数: 0

Abstract

The Janus kinase/signal transducer and activator of transfection (JAK/STAT) system is comprised of multiple cell surface receptors, receptor tyrosine kinases, and signal transducers that are key components of numerous systems involved in malignancy, inflammation, immune surveillance and development, cellular proliferation, metabolism, differentiation, apoptosis, and hematologic disorders, all of which when disrupted can produce severe disease. Nevertheless, small molecule inhibitors of the four known JAKs, termed JAKinibs, have found therapeutic indications for a broad category of diseases. In this perspective, I will summarize the development of JAK inhibitors, whose origins were in antiquity, with particular attention to their use in treating patients with inflammatory bowel disease (IBD). This perspective is accompanied by a companion publication addressing how JAKinibs have forever altered the landscape of IBD therapy.

有时小即是美:Janus激酶(JAK)和信号转导和转录激活因子(STAT)途径的发现以及用于IBD治疗的JAK抑制剂的初步开发。
Janus激酶/信号换能器和转染激活器(JAK/STAT)系统由多种细胞表面受体、受体酪氨酸激酶和信号换能器组成,它们是许多系统的关键组成部分,涉及恶性肿瘤、炎症、免疫监视和发育、细胞增殖、代谢、分化、凋亡和血液学疾病,所有这些系统一旦被破坏就会产生严重的疾病。然而,四种已知jak的小分子抑制剂,称为JAKinibs,已经发现了广泛类别疾病的治疗适应症。从这个角度来看,我将总结JAK抑制剂的发展,其起源可以追溯到古代,特别关注它们在治疗炎症性肠病(IBD)患者中的应用。这一观点伴随着一篇关于JAKinibs如何永远改变IBD治疗前景的同行出版物。
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来源期刊
Digestive Diseases and Sciences
Digestive Diseases and Sciences 医学-胃肠肝病学
CiteScore
6.40
自引率
3.20%
发文量
420
审稿时长
1 months
期刊介绍: Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.
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