Association of Fibrinogen Aα Thr312Ala (rs6050) Polymorphism with Venous Thrombosis and Chronic Thromboembolic Pulmonary Hypertension: A Meta-Analysis.

IF 2.3 4区 医学 Q2 HEMATOLOGY
Han Cheng, Haozhe Yang, Yantong Zhang, Zhanxu Wei, Lei Xia, Jing Yang
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Abstract

Background: Venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and pulmonary embolism (PE). Chronic thromboembolic pulmonary hypertension (CTEPH) typically arises from acute pulmonary embolism. The pathogenesis of them involves multiple risk factors such as genetic predisposition. However, the findings from these studies are not entirely consistent. This study aims to investigate the association between FGA rs6050 polymorphism and susceptibility to thrombotic diseases.

Methods: We searched PubMed, OVID, Web of Science, Academic Search Ultimate, CNKI, and Wan Fang database. To assess the strength of associations, we calculated pooled odds ratios (ORs) and 95% confidence intervals (CIs) in different genetic models. Additionally, subgroup analyses, sensitivity analysis, and assessment of publication bias were also carried out.

Results: A total of 11 studies, including 9 reported results on VTE (3856 individuals [1545 cases]) and 3 on CTEPH (761 participants [350 cases]), revealed a significant association between the rs6050 polymorphism and susceptibility to both VTE and CTEPH. The A allele was consistently linked to an elevated risk of VTE across all genetic models (allele, homozygote, heterozygote, recessive, and dominant model), while it was also associated with an increased risk of CTEPH under all genetic models excluding the recessive model. Furthermore, subgroup analysis among ethnic groups revealed a significant association between rs6050 polymorphisms and VTE in both Caucasians and Asians under all genetic models. In Africans, the association with VTE was only observed for rs6050 polymorphisms in dominant and heterozygous models.

Conclusions: The FGA rs6050 polymorphism is positively associated with susceptibility to VTE and CTEPH.

纤维蛋白原Aα Thr312Ala (rs6050)多态性与静脉血栓形成和慢性血栓栓塞性肺动脉高压的关联:一项荟萃分析
背景:静脉血栓栓塞(VTE)包括深静脉血栓形成(DVT)和肺栓塞(PE)。慢性血栓栓塞性肺动脉高压(CTEPH)通常由急性肺栓塞引起。其发病机制涉及遗传易感性等多种危险因素。然而,这些研究的结果并不完全一致。本研究旨在探讨FGA rs6050多态性与血栓性疾病易感性的关系。方法:检索PubMed、OVID、Web of Science、Academic Search Ultimate、CNKI、万方数据库。为了评估关联强度,我们计算了不同遗传模型的合并优势比(ORs)和95%置信区间(CIs)。此外,还进行了亚组分析、敏感性分析和发表偏倚评估。结果:共有11项研究,包括9项关于VTE(3856例[1545例])和3项关于CTEPH(761例[350例])的研究结果,揭示了rs6050多态性与VTE和CTEPH易感性之间的显著关联。在所有遗传模型(等位基因、纯合子、杂合子、隐性和显性模型)中,A等位基因始终与VTE风险升高相关,而在除隐性模型外的所有遗传模型中,A等位基因也与CTEPH风险增加相关。此外,族群间亚群分析显示,在所有遗传模型下,高加索人和亚洲人rs6050多态性与VTE之间存在显著关联。在非洲,仅在显性和杂合模型中观察到rs6050多态性与VTE的关联。结论:FGA rs6050多态性与VTE和CTEPH易感性呈正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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