Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2025-01-15 DOI:10.1186/s12876-025-03596-6

Mahyaar Omouri-Kharashtomi, Seyedeh Yasaman Alemohammad, Negin Moazed, Inas Afzali Nezhad, Hamed Ghoshouni

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引用次数: 0

Abstract

Background: Cholangiocarcinoma (CCA) is a type of cancer that develops in the biliary tract. CCA accounts for 10% of primary hepatic cancers and is characterized by its aggressive nature and poor prognosis. This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA.

Method: A comprehensive search was conducted on PubMed, Web of Science, Embase, and Scopus databases until August 11, 2023. Studies examining the prognostic impact of ALBI grade in patients with CCA were included. The prognostic effect was evaluated using hazard ratio (HR) with 95% confidence intervals (CI). The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). The final meta-analysis was performed using R version 4.3.1.

Results: The final meta-analysis included 13 studies with 3,434 patients. In univariate analysis (HR = 1.90, 95% CI: 1.65-2.19, P < 0.01) and multivariate analysis (HR = 1.88, 95% CI: 1.41-2.52, P < 0.01), higher ALBI grade was associated with lower overall survival (OS) in patients with intrahepatic CCA (ICCA). Higher ALBI grade was also correlated with decreased recurrence-free survival (RFS), with an HR of 1.63 (95% CI: 1.36-1.97, P < 0.01). Subgroup analysis of different ALBI grade comparisons showed consistent findings with our pooled data.

Conclusion: A high ALBI grade indicates poor OS and RFS in patients with CCA especially intrahepatic type. ALBI should be considered a reliable and clinically useful prognostic indicator.

Registration: PROSPERO ID: CRD42022379877.

查看原文本刊更多论文

胆管癌患者白蛋白-胆红素分级的预后价值：一项系统回顾和荟萃分析。

背景：胆管癌（CCA）是一种发生在胆道的肿瘤。CCA占原发性肝癌的10%，其特点是侵袭性和预后差。本系统综述和荟萃分析旨在评估新型肝功能评估指标白蛋白-胆红素（ALBI）分级在CCA患者中的预后价值。方法：截止2023年8月11日，对PubMed、Web of Science、Embase、Scopus等数据库进行综合检索。纳入了检查ALBI分级对CCA患者预后影响的研究。采用风险比（HR）和95%置信区间（CI）评估预后效果。纳入研究的质量采用纽卡斯尔-渥太华量表（NOS）进行评估。最后的meta分析使用R版本4.3.1进行。结果：最终荟萃分析包括13项研究，3,434例患者。单因素分析（HR = 1.90, 95% CI: 1.65-2.19， P）结论：高ALBI分级表明CCA患者特别是肝内型患者的OS和RFS较差。ALBI应被认为是一个可靠和临床有用的预后指标。注册：PROSPERO ID: CRD42022379877。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.