Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study.

IF 2.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

BMC Oral Health Pub Date : 2025-01-17 DOI:10.1186/s12903-024-05276-5

Razieh Zare, Leila Izadi, Mario Alberto Alarcón-Sánchez, Masumeh Taghva, Mohammad Ali Ranjbar

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引用次数: 0

Abstract

Background: Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and malignant salivary gland tumors by immunohistochemistry.

Methods: In this retrospective cross-sectional study, 68 cases including 25 pleomorphic adenomas (PAs), 21 adenoid cystic carcinomas (ADCa), 15 mucoepidermoid carcinomas (MEC), and 7 normal salivary glands (NSG) were enrolled from the archive of the Department of Pathology of Shiraz School of Dentistry, Iran. The expression of AurkA in the tissue samples was assessed by immunohistochemical method and was analyzed using statistical analysis (p < 0.05).

Results: Of total cases analyzed, the majority of benign and malignant tumors were found to involve minor salivary glands compared to major salivary glands (p < 0.001). In addition, all lesions studied expressed AurkA. More than half of the tumor tissues showed AurkA staining percentages between 26 and 50% and 76-100% compared to NSG (p = 0.08). In 44.1% of cases, cells had a weak staining score, 27.9% a moderate score and the rest (27.9%) a strong score (p = 0.64).

Conclusion: Although AurkA was observed to be expressed in all tumor tissues, further studies are needed to clearly understand the role of AurkA and the possibility of using it as a diagnostic, prognostic and therapeutic factor.

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唾液腺多形性腺瘤、腺样囊性癌和粘液表皮样癌中极光激酶A的表达：免疫组织化学研究。

背景：极光激酶A （AurkA）在有丝分裂中起着至关重要的作用，因此在肿瘤的发生和进展中起着关键作用。AurkA在唾液腺肿瘤中的表达研究较少。本研究的目的是通过免疫组织化学方法评估AurkA在最常见的良恶性唾液腺肿瘤中的表达规律。方法：回顾性分析来自伊朗设拉子牙科学院病理学系的68例患者，包括25例多形性腺瘤（PAs）、21例腺样囊性癌（ADCa）、15例粘液表皮样癌（MEC）和7例正常唾液腺（NSG）。应用免疫组织化学方法检测AurkA在组织样本中的表达，并进行统计学分析(p)。结果：在分析的所有病例中，良性和恶性肿瘤累及小唾液腺的比例高于大唾液腺(p)。虽然AurkA在所有肿瘤组织中都有表达，但需要进一步的研究来清楚地了解AurkA的作用以及将其作为诊断、预后和治疗因素的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

6.90%

发文量

481

审稿时长

6-12 weeks

期刊介绍： BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.